Characterization of familial hypercholesterolemia in Taiwanese ischemic stroke patients
| Autor: | Yung-Yang Lin, Hsin Tung, Chen-Chin Wu, Hsueh-Ju Lin, Jun-Peng Chen, Yi-Ming Chen, Tzu-Hung Hsiao, Tsai-Jung Lu, Po-Lin Chen, Pei-Pei Jhan |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Heterozygote Aging medicine.medical_specialty Apolipoprotein B carotid intima-media thickness Taiwan Familial hypercholesterolemia Hyperlipoproteinemia Type II Risk Factors Internal medicine ischemic stroke medicine Humans cardiovascular diseases Myocardial infarction Stroke Aged low-density lipoprotein cholesterol familial hypercholesterolemia biology business.industry PCSK9 Genetic disorder Cholesterol LDL Cell Biology Middle Aged Statin treatment medicine.disease Phenotype Receptors LDL Apolipoprotein B-100 Mutation Ischemic stroke Cardiology biology.protein Female atherosclerosis Proprotein Convertase 9 business Research Paper |
| Zdroj: | Aging (Albany NY) |
| ISSN: | 1945-4589 |
| DOI: | 10.18632/aging.203320 |
| Popis: | Familial hypercholesterolemia (FH) is a common genetic disorder characterized by a lifelong elevated low-density lipoprotein cholesterol (LDL-C) level. The relationship between FH and ischemic stroke is still controversial. We enrolled ischemic stroke patients prospectively in our neurological ward, and divided them into two groups according to LDL-C levels with a threshold of 130 mg/dl. Targeted sequencing was performed in all stroke patients for LDLR, APOB, and PCSK9 genes. The fifty-eight high-LDL subjects were older, prevalence of previous myocardial infarction/stroke history was lower, and the first stroke age was older compared with values in the sixty-three low-LDL cases. The prevalence of FH in Han-Chinese stroke patients was 5.0%, and was 10.3% in those with a higher LDL-C level. We identified six carriers, who had higher percentages of large vessel stroke subtype (66.7% vs. 15.4%) and transient ischemic attack (33.3% vs. 3.8%), previous myocardial infarction/stroke history (50.0% vs. 11.5%), statin use (50.0% vs. 11.5%), and increased carotid intima-media thickness (IMT) (0.9-1.2mm vs.0.7-9.0mm) compared with the other hypercholesterolemic patients without pathogenic variants. Ischemic stroke patients carrying FH pathogenic variants seemed to have a higher risk for large artery stroke and transient ischemic attack. The IMT exam could be useful to screen for FH in hypercholesterolemic stroke patients. |
| Databáze: | OpenAIRE |
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