Hybrid diamond/ carbon fiber microelectrodes enable multimodal electrical/chemical neural interfacing
| Autor: | Samira Falahatdoost, David J. Garrett, Young Jun Jung, Alastair Stacey, Melanie E.M. Stamp, Maryam Hejazi, Hamish Meffin, Michael R. Ibbotson, Jian Fang, Wei Tong, Nicholas V. Apollo, Aaqil Rifai, Kumaravelu Ganesan, Kate Fox, Artemio Soto-Breceda, Molis Yunzab, Athavan Nadarajah, Steven Prawer, Matias I. Maturana, Shi Sun, Ali Almasi |
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| Rok vydání: | 2020 |
| Předmět: |
Materials science
Biophysics Action Potentials Bioengineering 02 engineering and technology engineering.material Biomaterials 03 medical and health sciences Carbon Fiber 030304 developmental biology 0303 health sciences Carbon fiber microelectrode Diamond 021001 nanoscience & nanotechnology Electric Stimulation Treatment efficacy Microelectrode Electrophysiology Mechanics of Materials Interfacing Neural stimulation Electrode Ceramics and Composites engineering 0210 nano-technology Microelectrodes Biomedical engineering |
| Zdroj: | Biomaterials. 230:119648 |
| ISSN: | 0142-9612 |
| DOI: | 10.1016/j.biomaterials.2019.119648 |
| Popis: | Implantable medical devices are now in regular use to treat or ameliorate medical conditions, including movement disorders, chronic pain, cardiac arrhythmias, and hearing or vision loss. Aside from offering alternatives to pharmaceuticals, one major advantage of device therapy is the potential to monitor treatment efficacy, disease progression, and perhaps begin to uncover elusive mechanisms of diseases pathology. In an ideal system, neural stimulation, neural recording, and electrochemical sensing would be conducted by the same electrode in the same anatomical region. Carbon fiber (CF) microelectrodes are the appropriate size to achieve this goal and have shown excellent performance, in vivo. Their electrochemical properties, however, are not suitable for neural stimulation and electrochemical sensing. Here, we present a method to deposit high surface area conducting diamond on CF microelectrodes. This unique hybrid microelectrode is capable of recording single-neuron action potentials, delivering effective electrical stimulation pulses, and exhibits excellent electrochemical dopamine detection. Such electrodes are needed for the next generation of miniaturized, closed-loop implants that can self-tune therapies by monitoring both electrophysiological and biochemical biomarkers. |
| Databáze: | OpenAIRE |
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