Lacidipine has anti-atherosclerotic effects independent of its actions on lipid metabolism and blood pressure
| Autor: | Günay Yetik Anacak, Ozlem Yilmaz Dilsiz, Levent Üstünes, Adviye Ergul |
|---|---|
| Přispěvatelé: | Ege Üniversitesi |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Dihydropyridines Physiology Blood Pressure Nitric Oxide Article Nitric oxide chemistry.chemical_compound Internal medicine Isometric Contraction medicine Enhanced sensitivity Animals Collar-induced atherosclerosis Pharmacology Lacidipine Cholesterol business.industry Nitrotyrosine Lipid metabolism Atherosclerosis Calcium Channel Blockers Lipid Metabolism Intimal thickening Rabbit carotid artery Oxidative Stress Blood pressure Endocrinology Carotid Arteries chemistry Matrix Metalloproteinase 9 Molecular Medicine Female Endothelium Vascular Rabbits business MMP-9 Tunica Intima Vascular reactivity Acetylcholine 5-HT sensitivity medicine.drug |
| Popis: | WOS: 000284731000001 PubMed ID: 20709189 The antiatherosclerotic effect of lacidipine has been attributed to its actions on cholesterol levels, lipid metabolism or oxidant stress in advanced disease. The purpose of the present experiments was to examine whether lacidipine is protective of intimal thickening and vascular dysfunction in early atherosclerosis in the absence of the hypertension and hypercholesterolemia. A second goal was to determine whether and to what extent MMP-9 and oxidant stress are involved in possible beneficial effects of lacidipine. Lacidipine treatment (5 mg/kg/day, p.o. for 3 weeks) significantly prevented the collar-induced intimal thickening. MMP-9 expressions were increased by collar but not effected by lacidipine treatment Nitrotyrosine staining, a marker for oxidant stress was not changed neither by collar nor lacidipine treatment in early atherosclerosis. The enhanced sensitivity to serotonine and diminished sensitivity to acetylcholine in collared arteries were restored to normal levels with treatment. These results demonstrate that the lacidipine treatment prevents the collar-induced intimal thickening and accompanying vascular dysfunction in early atherosclerosis without cholesterol loading. These beneficial effects of lacidipine were not associated with changes in either MMP-9 expression or oxidant stress. However, enhanced endothelium-dependent relaxations by lacidipine, suggest that vascular protective effects of nitric oxide may be at least partly, responsible from antiatherosclerotic effects of lacidipine. (C) 2010 Elsevier Inc. All rights reserved. Turkish Academy of SciencesTurkish Academy of Sciences [G.Y.A/TUBA-GEBIP/2010-7]; Ege UniversityEge University [1995/ECZ/01]; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [DK074385] We would like to thank Dr. Arnold Herman (University of Antwerp, Belgium) for his help in providing lacidipine. A part of this work was supported by grants from the Turkish Academy of Sciences (G.Y.A/TUBA-GEBIP/2010-7), the Ege University Scientific Research Fund, 1995/ECZ/01 (G.Y.A), and from the NIH DK074385 (A.E.). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|