Comparative Sequences of Two Type 1 Dengue Virus Strains Possessing Different Growth CharacteristicsIn Vitro
| Autor: | Tsutomu Takegami, K Kamimura, Hisashi Funada, Hasanuddin Ishak |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Sequence analysis
viruses Immunology Genome Viral In Vitro Techniques Viral Nonstructural Proteins Biology Dengue virus medicine.disease_cause Microbiology Species Specificity Viral Envelope Proteins Sequence Homology Nucleic Acid Virology Chlorocebus aethiops medicine Animals Humans Coding region Amino Acid Sequence Vero Cells Peptide sequence chemistry.chemical_classification Genetics NS3 Base Sequence Sequence Homology Amino Acid Strain (chemistry) Nucleic acid sequence Dengue Virus Molecular biology Amino acid Amino Acid Substitution chemistry DNA Viral |
| Zdroj: | Microbiology and Immunology. 45:327-331 |
| ISSN: | 0385-5600 |
| DOI: | 10.1111/j.1348-0421.2001.tb02627.x |
| Popis: | The complete genome sequences of two dengue-1 virus strains having different growth characteristics (Mochizuki and A88) were compared with other published strains. The sequence analysis indicated several unique amino acid changes throughout the coding region of Mochizuki strain, mostly in envelope (E) protein. A unique amino acid, Ile-69 for Mochizuki strain at E protein resulted in the loss of an Asn-67-linked glycosylation site. A Thr substitution for Ala-114 at C protein and amino acid changes found in E, non-structural NS3, NS4a, and NS5 proteins were unique for A88 strain. These substitutions might be correlated to their different growth characteristics in vitro. |
| Databáze: | OpenAIRE |
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