pH Changes in the Micelle-Water Interface of Surface-Active Ionic Liquids Dictate the Stability of Encapsulated Curcumin: An Insight Through a Unique Interfacial Reaction between Arenediazonium Ions and

Autor:	Nighat Nazir, Mohd Sajid Lone, Aijaz Ahmad Dar, Saima Afzal
Rok vydání:	2021
Předmět:	chemistry.chemical_classification Hydroquinone General Chemical Engineering Kinetics General Chemistry Micelle Article Chemistry chemistry.chemical_compound Pulmonary surfactant chemistry Chemical engineering Ionic liquid Sodium dodecyl sulfate Counterion QD1-999 Alkyl
Zdroj:	ACS Omega ACS Omega, Vol 6, Iss 23, Pp 14985-15000 (2021)
ISSN:	2470-1343
Popis:	The chemical kinetic (CK) method, which involves the reduction of 4-hexadecylbenzenediazonium ions (16-ArN2 +) by antioxidants (in the present case, TBHQ) occurring exclusively at the interface of the association colloids, was employed to establish the changes in the chemical reactivity of anionic surface-active ionic liquids (SAILs) as a function of the concentration and the composition in their mixed states. We used sodium dodecyl sulfate and different SAILs based on the dodecylsulfate surfactant containing 1-alkyl-3-methylimidazolium cations as counterions having a varying alkyl chain length of 4 (bmim), 8 (omim), and 12 (ddmim) carbon atoms. The structural transitions of aggregates of the SAILs from the micellar to vesicular form were observed as a function of concentration in single surfactant systems and as a function of composition in mixed surfactant systems. Results of the reduction kinetics of 16-ArN2 + at the interface of such aggregates, which depends on the acid/base equilibria at the interface, gave an insight into the changes in the interfacial H+ ions with the change in the hydrophobicity of the counterions of SAILs and the morphological changes from micelles to vesicles as a function of concentration or composition. These changes in the interfacial pH correlate very well with the stability of curcumin within these self-assemblies, which exclusively depends on the pH of the medium and highlights the importance of the results obtained from the CK method in selecting the appropriate medium/conditions for the stabilization of the bioactive molecules.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ec2542346db2a50a9eea9425d210511 https://pubmed.ncbi.nlm.nih.gov/34151080 Zobrazit plný text záznamu