New half-sandwich ruthenium(II) complexes as proteosynthesis inhibitors in cancer cells

Autor:	Enrique Ortega, Fernando Domínguez, Nerea Davila-Ferreira, Delia Bautista, José Ruiz, Vanesa Porto, Viktor Brabec, M. Dolores Santana, Francisco J. Ballester, Hana Kostrhunova
Přispěvatelé:	Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Química Inorgánica
Rok vydání:	2019
Předmět:	Stereochemistry Cell Survival action mode chemistry.chemical_element Antineoplastic Agents Apoptosis CHO Cells 010402 general chemistry half-sandwich 01 natural sciences Catalysis Ruthenium Metal Structure-Activity Relationship Cricetulus Cell Line Tumor Materials Chemistry Organometallic Compounds Structure–activity relationship Animals Humans cancer Mode of action ruthenium Cell Proliferation Dose-Response Relationship Drug 010405 organic chemistry Chinese hamster ovary cell Metals and Alloys selectivity General Chemistry 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Neoplasm Proteins chemistry Cell culture visual_art Cancer cell Ceramics and Composites visual_art.visual_art_medium Drug Screening Assays Antitumor Selectivity
Zdroj:	DIGITUM: Depósito Digital Institucional de la Universidad de Murcia Universidad de Murcia DIGITUM. Depósito Digital Institucional de la Universidad de Murcia instname
Popis:	Half-sandwich ruthenium(ii) complexes [(η6-p-cymene)Ru(C^N)-(X)]0/+ (X = Cl, py or 4-NMe2-py) containing a cyclometalated 2-ppy or 1-ppz with a non-coordinated CHO group as a handle for further functionalization have been synthesized to achieve selective cytotoxicity to cancer cells, the more potent compounds acting as proteosynthesis inhibitors; this is a new mode of action for half-sandwich metal complexes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ec24b722993556818a62af563623173 http://hdl.handle.net/10201/101952 Zobrazit plný text záznamu