Comparison of bovine immune responses to affinity-purified bovine herpesvirus-1 antiidiotypes and glycoproteins
Autor: | Lorne A. Babiuk, D.J. Orten, D.N. Reddy, Frank Blecha, W. Xue, O. Y. Abdelmagid, S. van Drunen Littel-van den Hurk, H.C. Minocha, Manuel Campos |
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Rok vydání: | 1993 |
Předmět: |
Male
medicine.drug_class viruses animal diseases medicine.medical_treatment Immunology chemical and pharmacologic phenomena Monoclonal antibody Antibodies Viral Mice Viral Proteins Immune system Viral envelope Viral Envelope Proteins Virology medicine Animals Infectious Bovine Rhinotracheitis Herpesvirus 1 Bovine Immunity Cellular Mice Inbred BALB C biology virus diseases biochemical phenomena metabolism and nutrition biology.organism_classification Bovine herpesvirus 1 Recombinant Proteins Antibodies Anti-Idiotypic Polyclonal antibodies Humoral immunity biology.protein Molecular Medicine Interleukin-2 Cattle Antibody Adjuvant |
Zdroj: | Viral immunology. 6(2) |
ISSN: | 0882-8245 |
Popis: | Bovine immune responses to rabbit antiidiotypic antibodies (anti-Id) against neutralizing monoclonal antibodies to bovine herpesvirus-1 (BHV-1) envelope glycoproteins and to BHV-1 glycoproteins were compared. Glycoprotein-immunized animals produced high titers of anti-BHV-1 antibodies and were protected against BHV-1 challenge. Recombinant bovine interleukin-2 (rIL-2)-treated, anti-Id-immunized animals showed a slight reduction in clinical disease, and one calf produced BHV-1-neutralizing antibodies. Treatment with rIL-2 augmented non-BHV-1-specific immune responses. However, even with rIL-2 as an adjuvant, the mixture of polyclonal anti-Id did not elicit a consistent, protective BHV-1-specific immune response in calves. |
Databáze: | OpenAIRE |
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