Protein calorie malnutrition, nutritional intervention and personalized cancer care
| Autor: | Andre Goy, Gina Durante, Sung-Eun Choi, Young Hee Kim, Sakshi Balwani, Nehad M. Ayoub, Andrew L. Pecora, Ahmed Hassan, K. Stephen Suh, Anju Gangadharan |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Gerontology Pediatrics medicine.medical_specialty Cachexia Protein–energy malnutrition Nutritional Status Disease Clinical nutrition Review malnutrition nutritional intervention Protein-Energy Malnutrition 03 medical and health sciences 0302 clinical medicine Weight loss Neoplasms medicine Animals Humans Precision Medicine Wasting business.industry biomarkers medicine.disease Anorexia Clinical pharmacy Malnutrition 030104 developmental biology Oncology 030220 oncology & carcinogenesis cancer therapy medicine.symptom chemo treatment business Energy Metabolism |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Anju Gangadharan 1 , Sung Eun Choi 2 , Ahmed Hassan 1 , Nehad M. Ayoub 3 , Gina Durante 4 , Sakshi Balwani 1 , Young Hee Kim 4 , Andrew Pecora 5 , Andre Goy 5 and K. Stephen Suh 1 1 The Genomics and Biomarkers Program, JT Cancer Center, Hackensack University Medical Center, Hackensack Meridian Health, Hackensack, NJ, USA 2 Department of Family, Nutrition, and Exercise Sciences, Queens College, The City University of New York, Flushing, NY, USA 3 Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan 4 Department of Clinical Nutrition, Baystate Medical Center, Springfield, MA, USA 5 Clinical Divisions, JT Cancer Center, Hackensack University Medical Center, Hackensack Meridian Health, Hackensack, NJ, USA Correspondence to: K. Stephen Suh, email: // Keywords : malnutrition, cancer therapy, chemo treatment, biomarkers, nutritional intervention Received : July 25, 2016 Accepted : January 23, 2017 Published : February 04, 2017 Abstract Cancer patients often experience weight loss caused by protein calorie malnutrition (PCM) during the course of the disease or treatment. PCM is expressed as severe if the patient has two or more of the following characteristics: obvious significant muscle wasting, loss of subcutaneous fat; nutritional intake of 2% in 1 week, 5% in 1 month, or 7.5% in 3 months. Cancer anorexia-cachexia syndrome (CACS) is a multifactorial condition of advanced PCM associated with underlying illness (in this case cancer) and is characterized by loss of muscle with or without loss of fat mass. Cachexia is defined as weight loss of more than 5% of body weight in 12 months or less in the presence of chronic disease. Hence with a chronic illness on board even a small amount of weight loss can open the door to cachexia. These nutritional challenges can lead to severe morbidity and mortality in cancer patients. In the clinic, the application of personalized medicine and the ability to withstand the toxic effects of anti-cancer therapies can be optimized when the patient is in nutritional homeostasis and is free of anorexia and cachexia. Routine assessment of nutritional status and appropriate intervention are essential components of the effort to alleviate effects of malnutrition on quality of life and survival of patients. |
| Databáze: | OpenAIRE |
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