The Role of the Serotoninergic System in the Regulation of Thyroid Function in Old Rats
| Autor: | O. O. Masalova, N. S. Sapronov |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Aging Serotonin medicine.medical_specialty Thyroid Gland Methysergide Thyrotropin Citalopram Thyroid Function Tests Serotonergic General Biochemistry Genetics and Molecular Biology Thyrotropic cell Internal medicine medicine Animals Rats Wistar Triiodothyronine business.industry Tryptophan General Medicine Rats Thyroxine Endocrinology Thyroidectomy Thyroid function business Selective Serotonin Reuptake Inhibitors medicine.drug Hormone |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 148:815-818 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-010-0824-4 |
| Popis: | The effect of serotoninotropic substances with positive and negative effects on serum concentrations of thyrotropic hormone, total triiodothyronine, and total thyroxin was studied in old male rats. Chronic treatment with L-tryptophan and citalopram reduced serum level of total thyroxin in old intact animals and serum concentration of thyrotropic hormone in old thyrectomied rats. DL-p-chlorophenylalanine increased the serum concentrations of total thyroxin in old intact rats and in thyroidectomied animals treated with triiodothyronine. Chronic methysergide therapy was associated with reduction of serum concentration of thyrotropic hormone in old intact and old thyroidectomied rats and of total triiodothyronine in old intact animals. |
| Databáze: | OpenAIRE |
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