Specific localization of signal transducer and activator of transcription 1 immunoreactivity in oxytocin neurons of the rat hypothalamus
| Autor: | M. Chaigniau, Laurent Gautron, Sophie Layé |
|---|---|
| Přispěvatelé: | Unité mixte de recherche neurobiologie intégrative, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA) |
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty [SDV]Life Sciences [q-bio] Central nervous system Hypothalamus Ciliary neurotrophic factor Oxytocin LOCALISATION 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Animals STAT1 Rats Wistar Molecular Biology Transcription factor ComputingMilieux_MISCELLANEOUS 030304 developmental biology Neurons 0303 health sciences biology General Neuroscience Immunohistochemistry Rats Cell biology DNA-Binding Proteins STAT1 Transcription Factor Endocrinology medicine.anatomical_structure nervous system Trans-Activators biology.protein STAT protein RAT Neurology (clinical) Signal transduction 030217 neurology & neurosurgery Developmental Biology medicine.drug |
| Zdroj: | Brain Research Brain Research, Elsevier, 2003, 994, pp.260-264 |
| ISSN: | 0006-8993 |
| Popis: | The transcription factor STAT1 participates in signaling pathways and cellular responses triggered by several cytokines, growth factors and hormones. The present work demonstrates for the first time the immunohistochemical distribution of STAT1 in the rat hypothalamus. STAT1 immunoreactivity was observed in somas, dendrites and axons of neurons throughout the supraoptic and paraventricular nuclei and co-localized specifically with oxytocin. These findings indicate that STAT1 is positioned to participate in specific neuroendocrine regulation in the nonpathological rat brain. |
| Databáze: | OpenAIRE |
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