Palladium-Catalyzed Phenyl-Selenylation with n-Bu3SnSePh in One-Pot Two-Step Reactions

Autor:	Mariana Bonaterra, Roberto A. Rossi, Sandra E. Martin
Rok vydání:	2006
Předmět:	Aryl Organic Chemistry Two step chemistry.chemical_element General Medicine Biochemistry Stannane Coupling reaction Catalysis Metal chemistry.chemical_compound chemistry visual_art Drug Discovery Polymer chemistry visual_art.visual_art_medium Organic chemistry Selenium Palladium
Zdroj:	ChemInform. 37
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200635188
Popis:	We have studied the Pd-catalyzed cross-coupling reaction of a stannane derived from selenium n-Bu3SnSePh (1) with aryl and perfluoroalkyl iodides. Herein a very efficient one-pot two-step selenylation reaction to form a C–Se bond is reported. Ph2Se2 reacts with Na metal in liquid ammonia yielding PhSe− ions. To this solution n-Bu3SnCl was added to afford 1, which was introduced in the palladium-catalyzed coupling reaction without isolation. These reactions afford functionalized diarylselenides and phenylperfluroalkyl selenides from good to high yields (38–98%).
Databáze:	OpenAIRE
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