Genetic variants of the MAVS, MITA and MFN2 genes are not associated with leprosy in Han Chinese from Southwest China
| Autor: | Guo-Dong Li, Deng-Feng Zhang, Yong-Gang Yao, Heng Long, Xiao-An Li, Ling Xu, Dong Wang, Yu-Ye Li, Xiu-Feng Yu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Adult Male China Adolescent Single-nucleotide polymorphism Microbiology Polymorphism Single Nucleotide GTP Phosphohydrolases Mitochondrial Proteins 03 medical and health sciences Young Adult 0302 clinical medicine Asian People Leprosy Genotype Genetics medicine Humans Allele Child Molecular Biology Mycobacterium leprae Ecology Evolution Behavior and Systematics Genetic Association Studies Mitochondrial antiviral-signaling protein Adaptor Proteins Signal Transducing Aged biology Haplotype Membrane Proteins Middle Aged biology.organism_classification medicine.disease Virology 030104 developmental biology Infectious Diseases Case-Control Studies Child Preschool Female IRF3 030217 neurology & neurosurgery |
| Zdroj: | Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 45 |
| ISSN: | 1567-7257 |
| Popis: | Leprosy is a chronic infectious disease caused by Mycobacterium leprae (M. leprae), which has massive genomic decay and dependence on host metabolism. Accumulating evidence showed a crucial role of mitochondria in metabolism and innate immunity. We hypothesized that the mitochondrial-related antimicrobial/antiviral immune genes MAVS (mitochondrial antiviral signaling protein), MITA (mediator of IRF3 activation) and MFN2 (mitofusin 2) would confer a risk to leprosy. In this study, we performed a case-control study to analyze 11 tag and/or non-synonymous SNPs of the MAVS, MITA and MFN2 genes in 527 leprosy patients and 583 healthy individuals, and directly sequenced the three genes in 80 leprosy patients with a family history from Yunnan, Southwest China. We found no association between these SNPs and leprosy (including its subtypes) based on the frequencies of alleles, genotypes and haplotypes between the cases and controls. There was also no enrichment of potential pathogenic variants of the three genes in leprosy patients. Our results suggested that genetic variants of the MAVS, MITA and MFN2 genes might not affect the susceptibility to leprosy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect