Imaging of gliomas with Cis-4-[18F]fluoro-L-proline
| Autor: | Kurt Hamacher, Heinz Mühlensiepen, Friedrich Weber, Dirk Pauleit, Michael Jarosch, Frank W. Floeth, Heinz H. Coenen, Hans Herzog, KJ Langen |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Nervous system
Adult Male Cancer Research Pathology medicine.medical_specialty Proline Central nervous system Biology Sensitivity and Specificity Cis-4-(18F)fluoro-L-proline chemistry.chemical_compound Methionine Glioma Cell Line Tumor medicine Animals Humans Radiology Nuclear Medicine and imaging chemistry.chemical_classification Brain Neoplasms Penumbra Reproducibility of Results Middle Aged medicine.disease Rats Inbred F344 Amino acid Rats medicine.anatomical_structure chemistry Molecular Medicine Autoradiography Female Radiopharmaceuticals Tomography Emission-Computed |
| Zdroj: | Nuclear medicine and biology. 31(1) |
| ISSN: | 0969-8051 |
| Popis: | Tumor imaging with cis-4-[18F]fluoro-L-proline (cis-FPro) was compared to that of L-[3H]proline and L-[3H]methionine in F98 rat gliomas by dual-tracer autoradiography. All tracers exhibited high accumulation in the tumors but in the normal brain significant uptake was observed for L-[3H]methionine only. Tumor extent on autoradiograms with L-[3H]proline and L-[3H]methionine was identical to that of histological staining while autoradiograms of cis-FPro showed diffuse uptake in the penumbra of some tumors. First PET studies in 7 patients with cerebral gliomas demonstrated accumulation of cis-FPro in tumor areas with enhancement of Gd-DTPA on MR scans. Uptake of cis-FPro in normal brain tissue was negligible. In one patient with a glioblastoma accumulation of cis-FPro was also found in two brain areas without enhancement of Gd-DTPA on MR scans. Control of MRI suggested tumor growth in these areas at further follow up. Our results indicate that in most gliomas increased cis-FPro uptake is restricted to areas with disruption of the BBB which limits its clinical utility. |
| Databáze: | OpenAIRE |
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