Heterogeneity in hormone responses and patterns of collagen synthesis in cloned dermal fibroblasts
| Autor: | J H Korn, Stephen M. Krane, S. R. Goldring, E Downie, M. L. Stephenson |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
Cell Connective tissue Parathyroid hormone Matrix (biology) Biology Dinoprostone Dermis Cell surface receptor Internal medicine Cyclic AMP medicine Humans RNA Messenger Fibroblast Skin General Medicine Fibroblasts Clone Cells Cell biology medicine.anatomical_structure Endocrinology Parathyroid Hormone Collagen Procollagen Research Article Connective tissue cell |
| Zdroj: | Journal of Clinical Investigation. 85:798-803 |
| ISSN: | 0021-9738 |
| Popis: | Fibroblasts cultured from normal human dermis are heterogeneous with respect to growth kinetics, synthetic function, and morphologic features. There are many examples of clonal heterogeneity in apparently homogeneous connective tissue cell populations, and it has been suggested that selection of cell populations with particular phenotypic features is the basis for the development of pathologic connective tissue changes in inflammatory disorders. In these studies we report characterization of the pattern of matrix biosynthesis and responses to hormones in cells cloned from normal human dermis. The results indicate that cloned dermal fibroblasts are heterogeneous with respect to synthesis of collagens as well as their responses to prostaglandin E2 and parathyroid hormone. Selective expansion of clonal populations with unique patterns of matrix synthesis and cell surface receptors could provide the basis for abnormal connective tissue remodeling in certain pathologic states. |
| Databáze: | OpenAIRE |
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