Metabolic relevance for N-hydroxy l-arginine reduction in estrogen-negative breast cancer cells
| Autor: | Cathy Ng, Srinidi Mohan, Seema Patel, Lisa Harding, Ian Greenstein, Kelly Frazier, Giang Thi Tuyet Nguyen, David Barlow |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Arginine medicine.drug_class Clinical Biochemistry Breast Neoplasms Proteomics Biochemistry Nitric oxide 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Breast cancer Cell Line Tumor Humans Medicine business.industry Drug discovery Organic Chemistry Estrogens medicine.disease 030104 developmental biology Receptors Estrogen chemistry Estrogen 030220 oncology & carcinogenesis MCF-7 Cells Cancer research Biomarker (medicine) Female Breast cancer cells business |
| Zdroj: | Amino Acids. 50:1629-1636 |
| ISSN: | 1438-2199 0939-4451 |
| Popis: | We had shown Nw-hydroxy-l-arginine (NOHA) as a promising blood-based biomarker for estrogen-receptor-negative (ER−) breast cancer (BC) that differentiates ER− BC based on grade and molecular phenotype. In this in vitro study, we assessed the metabolic relevance for ER− BC-specific NOHA modulation and correlated them with NOHA regulatory responses. This study aids future NOHA clinical utility in ER− BC diagnosis and therapy management and would prove useful for potential drug discovery and development process. |
| Databáze: | OpenAIRE |
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