Significance of four MRD markers in MRD-based treatment strategy for childhood acute lymphoblastic leukemia
| Autor: | Naoki Sakata, Banryoku Higuchi, Tomoko Kishimoto, Emiko Sato, Akihisa Sawada, Keisei Kawa, Akira Yoshioka, Takayuki Okamura, Osamu Kondo, Maho Koyama, Masami Inoue, Masahiro Yasui |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty Pathology medicine.medical_treatment Antineoplastic Agents Hematopoietic stem cell transplantation Biology Flow cytometry hemic and lymphatic diseases Internal medicine Biomarkers Tumor medicine Humans Child Survival rate Childhood Acute Lymphoblastic Leukemia medicine.diagnostic_test Reverse Transcriptase Polymerase Chain Reaction Hematopoietic Stem Cell Transplantation Infant Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma Minimal residual disease Regimen Treatment Outcome Child Preschool Large study Treatment strategy Female |
| Zdroj: | Leukemia Research. 33:1710-1713 |
| ISSN: | 0145-2126 |
| DOI: | 10.1016/j.leukres.2009.06.016 |
| Popis: | Newly diagnosed children with ALL (n = 32) were treated on a protocol incorporating minimal residual disease (MRD)-based treatment decisions. MRD was monitored at 4 time points by semi-quantitative PCR detection of antigen receptor gene rearrangement, flow cytometry, quantitative RT-PCR detection of chimeric gene transcripts and overexpressed WT1 mRNA. Four patients positive for MRD at week 5 were treated with an intensified regimen. Median follow-up was 5.0 years (range 3.8–6.6 years) with a 4-year event-free survival rate of 93.8 ± 4.3%. This MRD-based treatment strategy seems to be highly successful and may improve the outcomes of children with ALL. A large study is warranted. |
| Databáze: | OpenAIRE |
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