Perivascular Adipose Tissue: the Sixth Man of the Cardiovascular System
| Autor: | Chak Kwong Cheng, Yu Huang, Hamidah Abu Bakar, Maik Gollasch |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Vascular wall Future studies Vascular smooth muscle Endothelium Adipose tissue Review Article KCNQ-type KV7 channels 030204 cardiovascular system & hematology 03 medical and health sciences Paracrine signalling 0302 clinical medicine Adipokines Beige adipocytes Paracrine Communication Adipocytes medicine Animals Humans Pharmacology (medical) Vascular Diseases Exercise Adiposity Perivascular relaxing factor Pharmacology business.industry Perivascular nerves General Medicine Beige Adipocytes Vascular tone Vasodilation MicroRNAs Phenotype 030104 developmental biology medicine.anatomical_structure Cellular Microenvironment PVRF Blood Vessels Cardiology and Cardiovascular Medicine business Neuroscience Signal Transduction |
| Zdroj: | Cardiovascular Drugs and Therapy |
| ISSN: | 1573-7241 0920-3206 |
| DOI: | 10.1007/s10557-018-6820-z |
| Popis: | Perivascular adipose tissue (PVAT) refers to the local aggregate of adipose tissue surrounding the vascular tree, exhibiting phenotypes from white to brown and beige adipocytes. Although PVAT has long been regarded as simply a structural unit providing mechanical support to vasculature, it is now gaining reputation as an integral endocrine/paracrine component, in addition to the well-established modulator endothelium, in regulating vascular tone. Since the discovery of anti-contractile effect of PVAT in 1991, the use of multiple rodent models of reduced amounts of PVAT has revealed its regulatory role in vascular remodeling and cardiovascular implications, including atherosclerosis. PVAT does not only release PVAT-derived relaxing factors (PVRFs) to activate multiple subsets of endothelial and vascular smooth muscle potassium channels and anti-inflammatory signals in the vasculature, but it does also provide an interface for neuron-adipocyte interactions in the vascular wall to regulate arterial vascular tone. In this review, we outline our current understanding towards PVAT and attempt to provide hints about future studies that can sharpen the therapeutic potential of PVAT against cardiovascular diseases and their complications. |
| Databáze: | OpenAIRE |
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