Genetic predisposition to long telomeres is associated with increased mortality after melanoma: A study of 2101 melanoma patients from hospital clinics and the general population
Autor: | Lars Bastholt, Henrik Schmidt, Lisbet Rosenkrantz Hölmich, Helle Klyver, Annette H. Chakera, Stig E. Bojesen, Børge G. Nordestgaard, Liv Schöllhammer, Pia Sjøgren, Hafsa Ismail, Jens Helby |
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Rok vydání: | 2021 |
Předmět: |
Adult
Male 0301 basic medicine Oncology medicine.medical_specialty Population Single-nucleotide polymorphism Dermatology Polymorphism Single Nucleotide survival Disease-Free Survival General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Telomere Homeostasis Internal medicine Genotype melanoma Genetic predisposition Humans Medicine Genetic Predisposition to Disease telomere homeostasis Allele education Melanoma Alleles Aged education.field_of_study business.industry Hazard ratio biomarkers Middle Aged Telomere mortality Neoplasm Proteins Survival Rate 030104 developmental biology 030220 oncology & carcinogenesis Female business |
Zdroj: | Ismail, H, Helby, J, Hölmich, L R, H. Chakera, A, Bastholt, L, Klyver, H, Sjøgren, P, Schmidt, H, Schöllhammer, L, Nordestgaard, B G & Bojesen, S E 2021, ' Genetic predisposition to long telomeres is associated with increased mortality after melanoma : A study of 2101 melanoma patients from hospital clinics and the general population ', Pigment Cell and Melanoma Research, vol. 34, no. 5, pp. 946-954 . https://doi.org/10.1111/pcmr.12971 Ismail, H, Helby, J, Hölmich, L R, Chakera, A H, Bastholt, L, Klyver, H, Sjøgren, P, Schmidt, H, Schöllhammer, L, Nordestgaard, B G & Bojesen, S E 2021, ' Genetic predisposition to long telomeres is associated with increased mortality after melanoma : a study of 2101 melanoma patients from hospital clinics and the general population ', Pigment Cell & Melanoma Research, vol. 34, no. 5, pp. 946-954 . https://doi.org/10.1111/pcmr.12971 |
ISSN: | 1755-148X 1755-1471 |
Popis: | Whether there is an association between measured and genetically predicted telomere length and melanoma mortality is unclear. We tested the hypotheses that measured and genetically predicted telomere length are associated with mortality after a melanoma diagnosis. We followed 2101patients with melanoma from hospital clinics and the general population for risk of death for up to 26 years. All had telomere length measured in DNA from leukocytes and 2052 of these were genotyped for the three single nucleotide polymorphisms rs7726159 (TERT), rs1317082 (TERC) and rs2487999 (OBFC1);all three genotypes are associated with telomere length, and combined into an allele count from 0 to 6. For each telomere-lengthening allele, the hazard ratios (HR) for mortality in the age-adjusted and multivariable adjusted Cox analysis were 1.12 (95% confidence interval: 1.02 - 1.23) and 1.11 (1.01 - 1.23).However, for each standard deviation increase in measured telomere length, HR for mortality was 0.97 (0.88 - 1.08). In conclusion, in more than 2000 melanoma patients from hospital clinics and from the general population, genetically predicted long telomeres were associated with increased mortality, but measured leukocyte telomere length was not. |
Databáze: | OpenAIRE |
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