Blood vessel injury may spur diseases fatal second phase
| Autor: | Catherine Matacic |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Blood vessel injury medicine.medical_specialty Multidisciplinary Coronavirus disease 2019 (COVID-19) business.industry Inflammation Disease 030204 cardiovascular system & hematology medicine.disease 03 medical and health sciences Pneumonia 030104 developmental biology 0302 clinical medicine Diabetes mellitus Internal medicine medicine Cardiology Young adult medicine.symptom Respiratory system business |
| Zdroj: | Science |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.368.6495.1039 |
| Popis: | As scientists have probed the deadly course of coronavirus—and realized that it is much more than a respiratory infection—they have zeroed in on how the virus damages blood vessels, finding blood clots in the lungs and other organs, inflammatory symptoms in children, and strokes in otherwise healthy young adults. Now, researchers have woven these findings into a new hypothesis explaining why some patients slip into a fatal "second phase" of COVID-19, 1 week or so after hospitalization. The key is direct and indirect damage to the endothelial cells that line the blood vessels, particularly in the lungs. By attacking those cells, COVID-19 infection causes vessels to leak and blood to clot, sparking inflammation throughout the body and fueling the acute respiratory distress syndrome responsible for most patient deaths. This mechanism could explain why the disease pummels some patients who have obesity, diabetes, and cardiovascular conditions: The cells lining their blood vessels are already compromised. If so, drugs already used to treat these conditions might help prevent other COVID-19 patients from sliding into serious disease. |
| Databáze: | OpenAIRE |
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