The influence of basic treatment with tiotropium bromide of patients with chronic obstructive pulmonary disease stage II on the morpho-functional state of bronchial mucosa and the level of type IV collagen in bronchoalveolar lavage fluid
| Autor: | Mariana Kulynych-Miskiv, Ksenia Ostrovska, Iryna Savelikhina, Mykola Osyrovskyy, Valentina Goncharuk |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.diagnostic_test Exacerbation business.industry lcsh:R lcsh:Medicine Dystrophy Connective tissue Tiotropium bromide Epithelium chronic obstructive pulmonary disease Type IV collagen Bronchoalveolar lavage medicine.anatomical_structure morphological rearrangement of the bronchial mucosa Edema medicine tiotropium bromide medicine.symptom business medicine.drug |
| Zdroj: | Galician Medical Journal; Vol. 25 No. 4 (2018) Galician Medical Journal; Том 25 № 4 (2018) Galician Medical Journal, Vol 25, Iss 4 (2018) Galician Medical Journal; Vol 25 No 4 (2018) |
| ISSN: | 2414-1518 2306-4285 |
| Popis: | The objective of the research was to evaluate the influence of basic treatment of patients with chronic obstructive pulmonary disease with tiotropium bromide on the processes of morphological rearrangement and local barrier defence mechanisms in the bronchial mucosa. Stage II chronic obstructive pulmonary disease is associated with the damage to the bronchi with proliferation of the connective tissue in its proper plate, clear identification of the basal membrane alteration, the presence of fibroblasts, the activation of fibroblasts/myofibroblasts and mucous glands, which is accompanied by the significant increase of type ІV collagen levels by 6.19 times (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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