The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome?
| Autor: | Francisco Gómez-Real, Kathrine Pape, Matthew G. Darby, Jorunn Kirkeleit, Simone Accordini, Lucia Calciano, Cecilie Svanes, Signe Timm, Toril Mørkve Knudsen, Jennifer J. Koplin, Ane Johannessen, Susanne Krauss-Etschmann, Ingrid Nordeide Kuiper, Randi Jacobsen Bertelsen, Gro Tjalvin, Svein Magne Skulstad, Juan Pablo López-Cervantes, Anne Mette Lund Würtz, Barbara Hammer, Shyamali C. Dharmage, Marianne Lønnebotn, Nils Oskar Jõgi, Vivi Schlünssen |
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| Přispěvatelé: | Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences |
| Rok vydání: | 2021 |
| Předmět: |
Lung Diseases
Exposome Health Toxicology and Mutagenesis Review Disease exposome Reproductive cycle Intergenerational Environmental health Allergies Hypersensitivity Humans Medicine Lung health transgenerational Life Style Lung function Organism Respiratory health Exposure assessment epigenetics allergies preconception business.industry Public Health Environmental and Occupational Health Preconception lung function Environmental Exposure asthma lung health Asthma Lifestyle factors intergenerational Epigenetics business Transgenerational |
| Zdroj: | International Journal of Environmental Research and Public Health López-Cervantes, J P, Lønnebotn, M, Jogi, N O, Calciano, L, Kuiper, I N, Darby, M G, Dharmage, S C, Gómez-Real, F, Hammer, B, Bertelsen, R J, Johannessen, A, Würtz, A M L, Knudsen, T M, Koplin, J, Pape, K, Skulstad, S M, Timm, S, Tjalvin, G, Krauss-Etschmann, S, Accordini, S, Schlünssen, V, Kirkeleit, J & Svanes, C 2021, ' The exposome approach in allergies and lung diseases : Is it time to define a preconception exposome? ', International Journal of Environmental Research and Public Health, vol. 18, no. 23, 12684 . https://doi.org/10.3390/ijerph182312684 International Journal of Environmental Research and Public Health (IJERPH) International Journal of Environmental Research and Public Health, Vol 18, Iss 12684, p 12684 (2021) |
| ISSN: | 1660-4601 |
| DOI: | 10.3390/ijerph182312684 |
| Popis: | Emerging research suggests environmental exposures before conception may adversely affect allergies and lung diseases in future generations. Most studies are limited as they have focused on single exposures, not considering that these diseases have a multifactorial origin in which environmental and lifestyle factors are likely to interact. Traditional exposure assessment methods fail to capture the interactions among environmental exposures and their impact on fundamental biological processes, as well as individual and temporal factors. A valid estimation of exposure preconception is difficult since the human reproductive cycle spans decades and the access to germ cells is limited. The exposome is defined as the cumulative measure of external exposures on an organism (external exposome), and the associated biological responses (endogenous exposome) throughout the lifespan, from conception and onwards. An exposome approach implies a targeted or agnostic analysis of the concurrent and temporal multiple exposures, and may, together with recent technological advances, improve the assessment of the environmental contributors to health and disease. This review describes the current knowledge on preconception environmental exposures as related to respiratory health outcomes in offspring. We discuss the usefulness and feasibility of using an exposome approach in this research, advocating for the preconception exposure window to become included in the exposome concept. |
| Databáze: | OpenAIRE |
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