The Role of Exosomal Epigenetic Modifiers in Cell Communication and Fertility of Dairy Cows
| Autor: | Eman Mohamed Othman Mosaad, Hassendrini N. Peiris, Natalie Turner, Murray D. Mitchell, Isabella Morean Garcia, Pevindu Abeysinghe |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
media_common.quotation_subject Fertility Cell Communication Review Biology Exosomes Extracellular vesicles Exosome Catalysis Epigenesis Genetic lcsh:Chemistry Inorganic Chemistry 03 medical and health sciences 0302 clinical medicine microRNA Animals exosome Epigenetics Physical and Theoretical Chemistry lcsh:QH301-705.5 Molecular Biology Spectroscopy media_common miRNA fertility epigenetics dairy cow Organic Chemistry General Medicine DNA Methylation Microvesicles Computer Science Applications Cell biology Dairying 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 Reduced fertility inflammation 030220 oncology & carcinogenesis Cattle Function (biology) |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 21, Iss 9106, p 9106 (2020) |
| ISSN: | 1422-0067 |
| Popis: | Abnormal uterine function affects conception rate and embryo development, thereby leading to poor fertility and reproduction failure. Exosomes are a nanosized subclass of extracellular vesicles (EV) that have important functions as intercellular communicators. They contain and carry transferable bioactive substances including micro RNA (miRNA) for target cells. Elements of the cargo can provide epigenetic modifications of the recipient cells and may have crucial roles in mechanisms of reproduction. The dairy industry accounts for a substantial portion of the economy of many agricultural countries. Exosomes can enhance the expression of inflammatory mediators in the endometrium, which contribute to various inflammatory diseases in transition dairy cows. This results in reduced fertility which leads to reduced milk production and increased cow maintenance costs. Thus, gaining a clear knowledge of exosomal epigenetic modifiers is critical to improving the breeding success and profitability of dairy farms. This review provides a brief overview of how exosomal miRNA contributes to inflammatory diseases and hence to poor fertility, particularly in dairy cows. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |