Drug-eluting fibers for HIV-1 inhibition and contraception
| Autor: | Cameron Ball, Kim A. Woodrow, Thanyanan Chaowanachan, Emily Krogstad |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
Polymers Nanofibers Human immunodeficiency virus (HIV) lcsh:Medicine HIV Infections 02 engineering and technology Pharmacology medicine.disease_cause Mice Drug Delivery Systems Engineering Pregnancy Medicine Materials Design lcsh:Science Sperm motility media_common 0303 health sciences Multidisciplinary Obstetrics and Gynecology 021001 nanoscience & nanotechnology Spermatozoa 3. Good health Contraception Drug delivery Monoglycerides Infectious diseases Female Material by Structure 0210 nano-technology Research Article Biotechnology Drug Drugs and Devices Anti-HIV Agents media_common.quotation_subject Materials Science HIV prevention Sexually Transmitted Diseases Bioengineering Viral diseases Biomaterials 03 medical and health sciences Contraceptive Agents Animals Humans Pharmacokinetics Biology 030304 developmental biology business.industry lcsh:R HIV Sperm Microbicides for sexually transmitted diseases Drug Liberation Physical Barrier Nanofiber HIV-1 Macaca lcsh:Q business Laurates |
| Zdroj: | PLoS ONE, Vol 7, Iss 11, p e49792 (2012) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Multipurpose prevention technologies (MPTs) that simultaneously prevent sexually transmitted infections (STIs) and unintended pregnancy are a global health priority. Combining chemical and physical barriers offers the greatest potential to design effective MPTs, but integrating both functional modalities into a single device has been challenging. Here we show that drug-eluting fiber meshes designed for topical drug delivery can function as a combination chemical and physical barrier MPT. Using FDA-approved polymers, we fabricated nanofiber meshes with tunable fiber size and controlled degradation kinetics that facilitate simultaneous release of multiple agents against HIV-1, HSV-2, and sperm. We observed that drug-loaded meshes inhibited HIV-1 infection in vitro and physically obstructed sperm penetration. Furthermore, we report on a previously unknown activity of glycerol monolaurate (GML) to potently inhibit sperm motility and viability. The application of drug-eluting nanofibers for HIV-1 prevention and sperm inhibition may serve as an innovative platform technology for drug delivery to the lower female reproductive tract. |
| Databáze: | OpenAIRE |
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