TRP ion channels in thermosensation, thermoregulation and metabolism
| Autor: | Jan Siemens, Hong Wang |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
somatosensation
medicine.medical_specialty dorsal root ganglion BBB blood-brain barrier Physiology Priority Review Tb body core temperature Biology TRP ion channels 03 medical and health sciences Transient receptor potential channel 0302 clinical medicine Physiology (medical) Internal medicine medicine nociception temperature homeostasis hypothalamus Ion channel 030304 developmental biology thermoregulation 0303 health sciences Metabolism Thermoregulation DRG dorsal root ganglion TG trigeminal ganglion Stretch-activated ion channel Endocrinology Temperature homeostasis thermosensation POA/AH preoptic area and anterior hypothalamus CFO circumferential organ Neuroscience Transduction (physiology) 030217 neurology & neurosurgery Function (biology) TRP transient receptor potential |
| Zdroj: | Temperature: Multidisciplinary Biomedical Journal |
| ISSN: | 2332-8959 2332-8940 |
| DOI: | 10.1080/23328940.2015.1040604 |
| Popis: | In humans, the TRP superfamily of cation channels includes 27 related molecules that respond to a remarkable variety of chemical and physical stimuli. While physiological roles for many TRP channels remain unknown, over the past years several have been shown to function as molecular sensors in organisms ranging from yeast to humans. In particular, TRP channels are now known to constitute important components of sensory systems, where they participate in the detection or transduction of osmotic, mechanical, thermal, or chemosensory stimuli. We here summarize our current understanding of the role individual members of this versatile receptor family play in thermosensation and thermoregulation, and also touch upon their immerging role in metabolic control. |
| Databáze: | OpenAIRE |
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