Hepatitis C virus molecular evolution: Transmission, disease progression and antiviral therapy
| Autor: | Carlos A. Vazquez-Chacon, Mayra Cruz-Rivera, Pamela Valva, Juan Carlos Carpio-Pedroza, María Victoria Preciado, Lílian Hiromi Tomonari Yamasaki, Salvador Fonseca-Coronado, Karina Ruiz-Tovar, Alejandro Escobar-Gutiérrez, Armando Martinez-Guarneros, Paula Rahal |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Hepatitis C Virus
CIENCIAS MÉDICAS Y DE LA SALUD Genotype Hepacivirus Hepatitis C virus Population Ciencias de la Salud medicine.disease_cause Antiviral Agents Virus Evolution Molecular purl.org/becyt/ford/3.3 [https] Genetic drift Molecular evolution Drug Resistance Viral medicine Animals Humans Topic Highlight education education.field_of_study Direct-Acting Antiviral Agents biology Genetic heterogeneity Gastroenterology virus diseases General Medicine Hepatitis C medicine.disease biology.organism_classification Virology digestive system diseases Enfermedades Infecciosas Phenotype Treatment Outcome Immunology Host-Pathogen Interactions Disease Progression Drug Therapy Combination purl.org/becyt/ford/3 [https] |
| Zdroj: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| Popis: | Hepatitis C virus (HCV) infection represents an important public health problem worldwide. Reduction of HCV morbidity and mortality is a current challenge owned to several viral and host factors. Virus molecular evolution plays an important role in HCV transmission, disease progression and therapy outcome. The high degree of genetic heterogeneity characteristic of HCV is a key element for the rapid adaptation of the intrahost viral population to different selection pressures (e.g., host immune responses and antiviral therapy). HCV molecular evolution is shaped by different mechanisms including a high mutation rate, genetic bottlenecks, genetic drift, recombination, temporal variations and compartmentalization. These evolutionary processes constantly rearrange the composition of the HCV intrahost population in a staging manner. Remarkable advances in the understanding of the molecular mechanism controlling HCV replication have facilitated the development of a plethora of direct-acting antiviral agents against HCV. As a result, superior sustained viral responses have been attained. The rapidly evolving field of anti-HCV therapy is expected to broad its landscape even further with newer, more potent antivirals, bringing us one step closer to the interferon-free era. Fil: Preciado, María Victoria. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Valva, Pamela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños ; Argentina Fil: Escobar Gutierrez, Alejandro. Instituto de Diagnóstico y Referencia Epidemiológicos; México Fil: Rahal, Paula. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil Fil: Ruiz Tovar, Karina. Instituto de Diagnóstico y Referencia Epidemiológicos; México Fil: Yamasaki, Lilian. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil Fil: Vazquez Chacon, Carlos. Instituto de Diagnóstico y Referencia Epidemiológicos; México Fil: Martinez Guarneros, Armando. Instituto de Diagnóstico y Referencia Epidemiológicos; México Fil: Carpio Pedroza, Juan Carlos. Instituto de Diagnóstico y Referencia Epidemiológicos; México Fil: Fonseca Coronado, Salvador. Universidad Nacional Autónoma de México; México Fil: Cruz Rivera, Mayra. Universidad Nacional Autónoma de México; México |
| Databáze: | OpenAIRE |
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