Soluble triggering receptor expressed on myeloid cells (sTREM-1): a new mediator involved in the pathogenesis of peptic ulcer disease
| Autor: | Georgios Tassias, Evangelos J. Giamarellos-Bourboulis, Vassilios Koussoulas, Spyridon Vassiliou, Helen Giamarellou, Maria D. Demonakou, Charalambos Barbatzas, Maria Mouktaroudi |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Peptic Gastroenterology Statistics Nonparametric Proinflammatory cytokine Pathogenesis Intestinal mucosa Malondialdehyde Internal medicine Biopsy medicine Humans Myeloid Cells Stomach Ulcer Intestinal Mucosa Receptors Immunologic Membrane Glycoproteins Hepatology medicine.diagnostic_test business.industry Stomach Interleukin-8 Middle Aged Triggering Receptor Expressed on Myeloid Cells-1 Cytokine medicine.anatomical_structure Duodenal Ulcer Cytokines Female Lipid Peroxidation Gastritis medicine.symptom business |
| Zdroj: | European Journal of Gastroenterology & Hepatology. 18:375-379 |
| ISSN: | 0954-691X |
| DOI: | 10.1097/00042737-200604000-00010 |
| Popis: | OBJECTIVES Triggering receptor expressed on myeloid cells (TREM-1) is a promoter of cytokine production triggered by microbial components. To investigate the significance of its soluble counterpart, sTREM-1, for the pathogenesis of peptic ulcer disease, sTREM-1 was compared with the proinflammatory mediators and the pathology score of gastritis. METHODS Forty patients with dyspepsia were enrolled: 20 with peptic ulcer and 20 controls without any macroscopic abnormalities. All patients were examined by endoscopy; gastric juice was aspirated and biopsy specimens were collected from the antrum and corpus of the stomach. sTREM-1 was estimated by a hand-made enzyme immunoassay. Interleukin-8 was estimated by enzyme-linked immunosorbent assay and lipid peroxidation, indexed by malondialdehyde, by the thiobarbituric assay, after passage through a high-performance liquid chromatography system. RESULTS The median (+/-SE) of sTREM-1 of controls and patients with ulcer was 3.91+/-0.57 and 44.27+/-241.55 RU, respectively (P=0.006). The median (+/-SE) of interleukin-8 of controls and patients with ulcer was 1802.97+/-122.10 and 2030.66+/-64.44 pg/ml, respectively (P=0.023). sTREM-1 was positively correlated with the density of neutrophil and mononuclear infiltration scores and the total Sydney score (P=0.029, 0.043 and 0.041, respectively). sTREM-1 was positively correlated with interleukin-8 (P=0.042). CONCLUSIONS sTREM-1 might be an independent factor involving with the peptic ulcerative inflammatory process that is positively correlated with histopathological abnormalities of gastritis. |
| Databáze: | OpenAIRE |
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