Triterpenoids with antiproliferative activities from the twigs and leaves of Melaleuca linariifolia
| Autor: | Zhen-Xing Zou, Fenghua Kang, Sha Zhang, Wei Hu, Wen-Xuan Wang, Kang-Ping Xu, Dekun Chen, Yin-Hua Deng, Chun-Mao Dong, Wei Wu |
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| Rok vydání: | 2020 |
| Předmět: |
Pharmacology
Traditional medicine biology 010405 organic chemistry Chemistry Organic Chemistry Myrtaceae Pharmaceutical Science Pentacyclic triterpenoids General Medicine biology.organism_classification 01 natural sciences 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry Triterpenoid Complementary and alternative medicine Pentacyclic triterpenoid Drug Discovery Molecular Medicine Melaleuca linariifolia |
| DOI: | 10.6084/m9.figshare.12600777.v1 |
| Popis: | One new pentacyclic triterpenoid, urs-12,16-dien-3-one (1), together with twelve known pentacyclic triterpenoids (2‒13), were isolated from the twigs and leaves of Melaleuca linariifolia. Their structures were characterized by their 1D- and 2 D-NMR spectra analysis and mass spectra studies. Furthermore, all isolated compounds were tested the inhibitory effect on proliferation of six human cancer cell lines in vitro, including NCI-H441, NCI-H460, A549, SKOV3, hela, and caki-1 cells. Among them, compounds 3, 5, 7, 9, 12, and 13 exhibited moderate antiproliferative activities with IC50 values ranging from 3.85 to 33.31 μM. |
| Databáze: | OpenAIRE |
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