Long Non-coding RNAs: A New Regulatory Code for Osteoporosis
| Autor: | Feng Zhang, Zong-Ning Miao, Xia Li, Jun-Xing Ye, Rui-Sheng Xu, Mingdong Zhao, Qian-Yuan Wu, Dong-Lin Jiang, Bei Wang, Feng Lai Yuan |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Endocrinology Diabetes and Metabolism Mini Review Osteoporosis Biology bone remolding Bioinformatics lcsh:Diseases of the endocrine glands. Clinical endocrinology Bone remodeling Metabolic bone disease 03 medical and health sciences long non-coding RNAs Endocrinology Osteoclast medicine Epigenetics Bone biology lcsh:RC648-665 osteoblasts Osteoblast medicine.disease osteoporosis 030104 developmental biology medicine.anatomical_structure osteoclasts Function (biology) |
| Zdroj: | Frontiers in Endocrinology, Vol 9 (2018) Frontiers in Endocrinology |
| ISSN: | 1664-2392 |
| Popis: | Osteoporosis is a metabolic bone disease characterized by a decrease in bone mass and degradation of the bone microstructure, which increases bone fragility and fracture risk. However, the molecular mechanisms of osteoporosis remain unclear. Long non-coding RNAs (lncRNAs) have become important epigenetic regulators controlling the expression of genes and affecting multiple biological processes. Accumulating evidence of the involvement of lncRNAs in bone remolding has increased understanding of the molecular mechanisms underlying osteoporosis. This review aims to summarize recent progress in the elucidation of the role of lncRNAs in bone remodeling, and how it contributes to osteoblast and osteoclast function. This knowledge will facilitate the understanding of lncRNA roles in bone biology and shed new light on the modulation and potential treatment of osteoporosis. |
| Databáze: | OpenAIRE |
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