Stimulation of Prolactin and Growth Hormone Secretion by Muscimol, a γ-Aminobutyric Acid Agonist*
| Autor: | Andreas Neophytides, Lawrence A. Frohman, Carol A. Tamminga, Thomas N. Chase |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Adult
Male Agonist endocrine system medicine.medical_specialty medicine.drug_class Endocrinology Diabetes and Metabolism Clinical Biochemistry Stimulation Biochemistry Aminobutyric acid chemistry.chemical_compound Endocrinology Oral administration Internal medicine medicine Humans Oxazoles gamma-Aminobutyric Acid Aged Hydrocortisone Muscimol Biochemistry (medical) Middle Aged Growth hormone secretion Prolactin Kinetics Huntington Disease chemistry Growth Hormone Chronic Disease Schizophrenia Female hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 47:1348-1351 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-47-6-1348 |
| Popis: | The alteration in circulating levels of PRL, GH, TSH, and cortisol was studied after the oral administration of muscimol (3-hydroxy-5-aminomethylisoxazole) to human subjects with Huntington's disease (n = 4) and chronic schizophrenia (n = 5). PRL levels rose significantly in a dose-dependent fashion within a 120-min time interval. GH rose significantly but modestly over the same time interval, whereas TSH and cortisol levels remained unchanged. Since muscimol is thought to be a potent and specific gamma-aminobutyric acid agonist, these data indicate that gamma-aminobutyric acid-mediated neural transmission may function to stimulate the release of plasma PRL and GH in human subjects. |
| Databáze: | OpenAIRE |
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