Hepatic expression responses of DNA methyltransferases, heat shock proteins, antioxidant enzymes, and NADPH 4 to early life thermal conditioning in broiler chickens
| Autor: | Mahmoud Alagawany, Mohamed S. El-Kholy, N. A. A. El-Azeem, Mahmoud Madkour, Ahmed A. Elolimy, Mohamad M. Aboelenin, Osama Aboelazab, Mohamed Shourrap |
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| Rok vydání: | 2021 |
| Předmět: |
animal structures
Antioxidant Methyltransferase thermal conditioning 040301 veterinary sciences medicine.medical_treatment SF1-1100 heat stress 0403 veterinary science chemistry.chemical_compound Heat shock protein medicine broiler chickens chemistry.chemical_classification 0402 animal and dairy science Broiler 04 agricultural and veterinary sciences 040201 dairy & animal science Animal culture Cell biology thermotolerance acquisition Thermal conditioning Enzyme chemistry Molecular mechanism Animal Science and Zoology molecular mechanism DNA |
| Zdroj: | Italian Journal of Animal Science, Vol 20, Iss 1, Pp 433-446 (2021) |
| ISSN: | 1828-051X |
| Popis: | Early-life thermal conditioning (TC) in broiler chickens has long-lasting impacts on later life. Therefore, this study aimed to clarify the molecular mechanism by which TC impacts the hepatic expression heat shock proteins (hsps), antioxidant enzymes, NADPH oxidase 4 (NOX4), glucocorticoid receptor (GR), and DNA methyltransferases genes in broiler chicks at five weeks of age. Two hundred forty one-day-old male broiler chicks of Cobb 500 were allocated into four equal experimental groups. The first group was under the optimal brooding conditions (control), whereas the 2nd, 3rd, and 4th groups were exposed to TC at 39 ± 1 °C for six hours on the third-, fifth- or seventh-day post-hatch, respectively. At 35 days of age, all chicks of four experimental groups were subjected to heat challenge by exposure to 36 ± 1 °C for six hours. Results showed that broilers exposed to TC on the fifth-day post-hatch when exposed to acute heat stress at five weeks of age had the lowest plasma CORT level, the lowest expression (p |
| Databáze: | OpenAIRE |
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