Holford NHG and Sheiner LB 'Understanding the Dose-Effect Relationship-Clinical Application of Pharmacokinetic-Pharmacodynamic Models', Clin Pharmacokin 6:429–453 (1981)—The Backstory
| Autor: | Nicholas H. G. Holford |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Pharmacology
medicine.medical_specialty Personal interest Dose-Response Relationship Drug business.industry Pharmacokinetic pharmacodynamic education Pharmaceutical Science Pharmacy Models Theoretical Acetyl choline Pharmacometrics Commentary Medicine Medical physics Pharmacokinetics Student training Dose-effect relationship Guinea pig ileum business |
| Popis: | My personal interest in understanding the dose–concentration–effect relationship started during my medical student training at the University of Manchester in England. In 1967, the Department of Pharmacology introduced a 1-year Bachelor of Science degree which medical students could take between their second and third years of the medical course. Only two students applied and that is how I was accepted for an intensive, practical course in pharmacology. One of the first laboratory sessions was to study the contractions of a segment of guinea pig ileum in response to acetyl choline (Fig. 1). This taught me the difference between dose and concentration, the asymptotic nature of the concentration–effect relationship, and the often inexplicable variability of biological systems (What happened to the response at 16 ng/mL?). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|