A hierarchical transcriptional network activates specific CDK inhibitors that regulate G2 to control cell size and number in Arabidopsis
| Autor: | Kesuke Yamada, Jing An, Magdolna Gombos, Takamasa Suzuki, Ying Huang, Moussa Benhamed, Cécile Raynaud, Christian Breuer, László Bögre, Miyu Imamura, Kenichiro Maeo, Masaki Ito, Zoltán Magyar, Takashi Ishida, David Latrasse, Keiko Sugimoto, Yuji Nomoto, Toshiya Suzuki, Takafumi Yamashino, Hirotomo Takatsuka |
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| Přispěvatelé: | Kanazawa University (KU), National Institute of Genetics (NIG), Chubu University, Institut des Sciences des Plantes de Paris-Saclay (IPS2 (UMR_9213 / UMR_1403)), Université d'Évry-Val-d'Essonne (UEVE)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Biological Research Centre [Szeged] (BRC), RIKEN Center for Integrative Medical Sciences [Yokohama] (RIKEN IMS), RIKEN - Institute of Physical and Chemical Research [Japon] (RIKEN), Nagoya University, The University of Tokyo (UTokyo), Biological Research Centre [Budapest] (BRC), Hungarian Academy of Sciences (MTA), Royal Holloway [University of London] (RHUL), The Japan Society for the Promotion of Science KAKENHI(20H05408 and 17H03696 to M.I., 20H05911 and 20H05905)Japan Science and Technology Agency (JST grant number JPMJPF2102 Institut Universitaire de FranceChina Scholar Council fellowships (201806690005) |
| Rok vydání: | 2021 |
| Předmět: |
Cell biology
[SDV]Life Sciences [q-bio] Arabidopsis General Physics and Astronomy General Biochemistry Genetics and Molecular Biology Cyclin-dependent kinase Transcription (biology) Endoreduplication [CHIM]Chemical Sciences Gene Regulatory Networks Transcription factor Gene Cell Size Organ growth Multidisciplinary biology Kinase Arabidopsis Proteins Cell Cycle General Chemistry Cell cycle biology.organism_classification biology.protein Transcription Factors |
| Zdroj: | Nature Communications Nature Communications, 2022, 13 (1), pp.1-16. ⟨10.1038/s41467-022-29316-2⟩ |
| ISSN: | 2041-1723 |
| Popis: | How cell size and number are determined during organ development remains a fundamental question in cell biology. Here, we identified a GRAS family transcription factor, called SCARECROW-LIKE28 (SCL28), with a critical role in determining cell size in Arabidopsis. SCL28 is part of a transcriptional regulatory network downstream of the central MYB3Rs that regulate G2 to M phase cell cycle transition. We show that SCL28 forms a dimer with the AP2-type transcription factor, AtSMOS1, which defines the specificity for promoter binding and directly activates transcription of a specific set of SIAMESE-RELATED (SMR) family genes, encoding plant-specific inhibitors of cyclin-dependent kinases and thus inhibiting cell cycle progression at G2 and promoting the onset of endoreplication. Through this dose-dependent regulation of SMR transcription, SCL28 quantitatively sets the balance between cell size and number without dramatically changing final organ size. We propose that this hierarchical transcriptional network constitutes a cell cycle regulatory mechanism that allows to adjust cell size and number to attain robust organ growth. |
| Databáze: | OpenAIRE |
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