Association of physical activity with risk of hepatobiliary diseases in China: a prospective cohort study of 0.5 million people
| Autor: | Derrick A Bennett, Ling Yang, Yiping Chen, Jun Lv, Liming Li, Michael V. Holmes, Huaidong Du, Zheng Bian, Junshi Chen, Canqing Yu, Hui Li, Christiana Kartsonaki, Hao Wang, Iain Turnbull, Yuanjie Pang, Zhengming Chen, Yu Guo |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male China medicine.medical_specialty Digestive System Diseases physical activity Physical Therapy Sports Therapy and Rehabilitation liver Metabolic equivalent 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Epidemiology cancer Humans Medicine Orthopedics and Sports Medicine Prospective Studies 030212 general & internal medicine Gallbladder cancer Prospective cohort study Exercise Original Research Aged business.industry Hepatobiliary disease Fatty liver Cancer General Medicine Middle Aged medicine.disease 3. Good health 030220 oncology & carcinogenesis Population study epidemiology Female business |
| Zdroj: | British Journal of Sports Medicine |
| ISSN: | 1473-0480 0306-3674 |
| Popis: | ObjectiveThere is limited prospective evidence on the association of physical activity with hepatobiliary cancer subtypes and other major hepatobiliary diseases, especially in China. We aimed to quantify the associations with risk of these diseases.MethodsThe study population involved 460 937 participants of the prospective China Kadoorie Biobank aged 30–79 years from 10 diverse areas in China without history of cancer or hepatobiliary disease at baseline. Cox regression was used to estimate adjusted hazard ratios (HRs) for each disease associated with self-reported total and domain-specific physical activity (occupational and non-occupational, ie, leisure time, household and commuting).ResultsDuring ~10 years of follow-up, 22 012 incident cases of hepatobiliary diseases were recorded. The overall mean (SD) total physical activity was 21.2 (13.9) metabolic equivalent of task (MET)-hours/day, with 62% from occupational activity. Total physical activity was inversely associated with hospitalised non-alcoholic fatty liver disease (HR comparing top vs bottom quintile: 0.62, 95% confidence interval (CI) 0.53 to 0.72), viral hepatitis (0.73, 95% CI 0.62 to 0.87), cirrhosis (0.76, 95% CI 0.66 to 0.88) and liver cancer (0.81, 95% CI 0.71 to 0.93), as well as gallstone disease (0.86, 95% CI 0.81 to 0.90), gallbladder cancer (0.51, 95% CI 0.32 to 0.80) and biliary tract cancer (0.55, 95% CI 0.38 to 0.78). The associations for occupational physical activity were similar to those for total physical activity, but for non-occupational physical activity they differed by disease subtype. For leisure-time physical activity, there was an inverse association with liver cancer and an inverse trend for gallstone disease (HR comparing ≥7.5 MET-hours/day with none: 0.83, 95% CI 0.75 to 0.91 and 0.82, 95% CI 0.66 to 1.01).ConclusionAmong Chinese adults, high total physical activity, particularly occupational physical activity, was inversely associated with risk of major hepatobiliary cancers and diseases, including non-alcoholic fatty liver disease, cirrhosis and certain types of cancer. |
| Databáze: | OpenAIRE |
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