Saline lavage for the management of severe pleural empyema: A cohort study

Autor:	Pere Trias-Sabrià, Hervé Dutau, Sophie Laroumagne, Julien Guinde, Bertrand Chollet, Philippe Astoul
Rok vydání:	2021
Předmět:	Pulmonary and Respiratory Medicine medicine.medical_specialty medicine.medical_treatment Cohort Studies medicine Immunology and Allergy Humans Therapeutic Irrigation Saline Genetics (clinical) Empyema Pleural Retrospective Studies medicine.diagnostic_test business.industry Pleural empyema Retrospective cohort study respiratory system medicine.disease Empyema respiratory tract diseases Surgery Chest tube Pleural Effusion Effusion Saline Solution Chest radiograph business Cohort study
Zdroj:	The clinical respiratory journalREFERENCES. 15(10)
ISSN:	1752-699X
Popis:	BACKGROUND Despite advances in the treatment of pleural infection, up to 20% of patients die. So far, studies assessing the role of intrapleural saline lavage for the management of all stage pleural infections are very scarce, usually excluding patients with cancer. METHODS The method used was a retrospective cohort study including pleural empyema managed with a pleural lavage of saline solution through a small-bore chest tube. The primary outcome was the rate of failure at 3 months (surgical referral or additional pleural manoeuver due to recurrent infection or all-cause mortality). Secondary outcomes were hospital stay, the change of the chest radiograph and inflammatory biomarkers, and complications. RESULTS Thirty patients with pleural empyema were included, 11 (36.7%) with an active cancer. The overall rate of failure at 3 months was 13.3% (surgical referral = 0; additional pleural manoeuver = 3; mortality = 1). Median length of pleural lavage and hospital stay were, respectively, 14 days (7-28) and 17 days (11-42). Inflammatory markers and size of the effusion on chest radiograph significantly decreased for Day 0 to Day 14. No chest tube blockade was reported, but seven (23.3%) accidentally withdrew. No other side effects were reported. CONCLUSIONS Intrapleural saline lavage is efficient and safe for the management of pleural empyema, even in severe status patients with cancer, at the cost of a prolonged hospitalization.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ea28a335a0fa7539f84dcab0d4f0ec7 https://pubmed.ncbi.nlm.nih.gov/34216522 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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