The possible role of zinc and metallothionein in the liver on the therapeutic effect of IFN-α to hepatitis C patients
| Autor: | Yoshiaki Hashimoto, Ryuya Shimoda, Keiji Suzuki, Takeaki Nagamine, Katsuyuki Nakajima, Masatomo Mori, Hisashi Takayama, Naruo Nomura, Hitoshi Takagi |
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| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Clinical Biochemistry chemistry.chemical_element Alpha interferon Zinc Biochemistry Inorganic Chemistry Basal (phylogenetics) Interferon Internal medicine Humans Metallothionein Medicine Analysis of Variance business.industry Spectrophotometry Atomic Biochemistry (medical) Therapeutic effect Interferon-alpha General Medicine Hepatitis C Hepatitis C Chronic Middle Aged medicine.disease Immunohistochemistry Endocrinology Liver chemistry Zinc deficiency Female business Copper medicine.drug |
| Zdroj: | Biological Trace Element Research. 58:65-76 |
| ISSN: | 1559-0720 0163-4984 |
| Popis: | We have studies zinc deficiency in hepatitis C patients (complete responder [CR] 22, nonresponder [NR] 25) with relation to the therapeutic effect of interferon-alpha (IFN-alpha). Circadian variations in serum zinc levels were high in the morning (basal level) and then gradually decreased during the day in both chronic hepatitis C patients and healthy controls. Basal zinc levels in serum were significantly lower in chronic hepatitis C patients (73 +/- 3 micrograms/dL, n = 12) than in controls (93 +/- 5 micrograms/dL). An injection of 10 MU of IFN-alpha to hepatitis C patients augmented the serum zinc reductions, up to 40% in 8 h. Serum cortisol levels were significantly elevated 8 h (25.6 +/- 2.3 micrograms/dL) after IFN-alpha dose. Forty-seven chronic hepatitis C patients were treated with IFN-alpha for 24 wk, and serum zinc and copper levels were determined 12 and 24 wk during and after the completion of IFN-alpha therapy. Serum zinc levels and zinc/copper ratio were higher in CRs than in NRs to IFN therapy at each time-point. Hepatic metallothionein staining became prominent after IFN therapy in most of CRs, whereas it diminished NRs. These data suggest that nutritional status of zinc influences the effect of IFN on hepatitis C patients. |
| Databáze: | OpenAIRE |
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