Evaluation of the morphological features and unfavorable prognostic impact of dirty necrosis in renal cell carcinoma
| Autor: | Genichiro Ishii, Hitoshi Masuda, Nobuaki Matsubara, Motohiro Kojima, Takashi Kuroe, Masato Sugano, Takeshi Kuwata, Ryo Morisue, Tetsuo Ushiku, Reiko Watanabe, Shioto Oda, Shota Kusuhara |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Cancer Research medicine.medical_specialty Pathology Necrosis medicine.medical_treatment Nephrectomy 03 medical and health sciences 0302 clinical medicine Renal cell carcinoma Internal medicine medicine Humans Carcinoma Renal Cell Aged Retrospective Studies Hematology Tumor size business.industry General Medicine medicine.disease Prognosis Kidney Neoplasms Survival Rate Dirty necrosis 030104 developmental biology Oncology 030220 oncology & carcinogenesis Tumor necrosis factor alpha Female medicine.symptom business Stage iv Follow-Up Studies |
| Zdroj: | Journal of cancer research and clinical oncology. 147(4) |
| ISSN: | 1432-1335 |
| Popis: | Tumor necrosis (TN) is one of the unfavorable prognostic factors in renal cell carcinoma (RCC). We identified two patterns of TN according to their morphology: dirty necrosis and ghost necrosis. We aimed to elucidate the morphological features and unfavorable prognostic impact of dirty necrosis in RCC. A total of 261 tumors collected after nephrectomy, which were pathologically identified as RCC, were analyzed in this study. We classified TN as dirty necrosis or ghost necrosis and compared their clinicopathological features. We also assessed their morphological features using digitally analyzed slides. The correlation between tumor size and necrosis area or the number of necrotic foci was calculated. There were 77 tumors (30%) with TN, and the presence of TN was significantly associated with unfavorable clinicopathological factors. Thirty tumors (39%) had dirty necrosis, and 47 tumors (61%) had ghost necrosis. There were significantly higher numbers of unfavorable factors associated with dirty necrosis than with ghost necrosis. In dirty necrosis, both the TN area and the number of necrotic foci were correlated with tumor size (p |
| Databáze: | OpenAIRE |
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