Bone healing response to a synthetic calcium sulfate/β-tricalcium phosphate graft material in a sheep vertebral body defect model
| Autor: | L Chen, D C Mangham, X S Zhu, S S Aiken, L A Coulton, Huilin Yang, C M Chen |
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| Rok vydání: | 2012 |
| Předmět: |
Calcium Phosphates
X-ray microtomography Materials science Bone Regeneration Time Factors Biomedical Engineering Dentistry chemistry.chemical_element Bone healing Calcium Bone tissue Calcium Sulfate Article Biomaterials kyphoplasty Osteogenesis Absorbable Implants Materials Testing medicine Animals Polymethyl Methacrylate Bone regeneration Bone growth bone cement Sheep business.industry Bone Cements X-Ray Microtomography Bone cement β-tricalcium phosphate PMMA Spine Resorption Disease Models Animal medicine.anatomical_structure chemistry Spinal Injuries Bone Substitutes vertebroplasty business Biomedical engineering |
| Zdroj: | Journal of Biomedical Materials Research. Part B, Applied Biomaterials |
| ISSN: | 1552-4981 |
| Popis: | The introduction of a material able to promote osteogenesis and remodelling activity in a clinically relevant time frame in vertebroplasty and kyphoplasty procedures may have patient benefit. We report the in-vivo performance of a biphasic synthetic bone graft material (Genex Paste, Biocomposites, UK) [test material], composed of calcium sulfate and β-tricalcium phosphate, implanted into a sheep vertebral defect model. Cavities drilled into 4 adjacent vertebrae (L2 to L5) of 24 skeletally mature sheep were; (1) filled with the test material; (2) filled with commercially available polymethylmethacrylate [PMMA] cement; (3) remained empty [sham]. Analysis was performed immediately after implantation and at 8, 16, and 36 weeks post implantation. Sites were evaluated for bone growth with microCT analysis, histological examination, and mechanical testing under compression. The test material exhibited an improved tissue response over the PMMA, indicating a superior biological tolerance. MicroCT and histology indicated marked osteoregenerative capacity of the test material when compared with sham and the PMMA. The percentage of new bone formation was higher for the test material than sham at 16 and 36 weeks post implantation, with bone regeneration almost complete at 36 weeks in this group. Resorption of test material and the integration into new bone tissue were demonstrated. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012. |
| Databáze: | OpenAIRE |
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