Correction: Modeling suggests that microliter volumes of contaminated blood caused an outbreak of hepatitis C during computerized tomography
| Autor: | Ilana Dery, Ran Tur-Kaspa, Eyal Shteyer, Harel Dahari, Gabriel S. Breuer, Inna Gafanovich, Yoav Lurie, Dana G. Wolf, Daniela Armoni, Adi Stern, Louis M. Shekhtman, Michal Cohen Eliav, Rima Barsuk, Scott J. Cotler, Rahul Pipalia, Yizhak Skorochod, Mila Rivkin, Sheri Harari, Tal Zinger, Yonit Weil Wiener, Hefziba Ivgi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Adolescent Genotype medicine.medical_treatment Hepatitis C virus lcsh:Medicine Contrast Media Hepacivirus Saline flush medicine.disease_cause Vial Gastroenterology Disease Outbreaks 03 medical and health sciences 0302 clinical medicine Viral Envelope Proteins Internal medicine medicine Humans lcsh:Science Saline Aged Cross Infection Multidisciplinary Models Statistical business.industry Transmission (medicine) lcsh:R Outbreak Correction Hepatitis C Viral Load medicine.disease 030104 developmental biology Needles RNA Viral 030211 gastroenterology & hepatology lcsh:Q Administration Intravenous Female Saline Solution business Drug Contamination Tomography X-Ray Computed Viral load |
| Zdroj: | PLoS ONE PLoS ONE, Vol 14, Iss 2, p e0212252 (2019) |
| ISSN: | 1932-6203 |
| Popis: | BACKGROUND & AIMS Acute hepatitis C (AHC) is not frequently identified because patients are usually asymptomatic, although may be recognized after iatrogenic exposures such as needle stick injuries, medical injection, and acupuncture. We describe an outbreak of AHC among 12 patients who received IV saline flush from a single multi-dose vial after intravenous contrast administration for a computerized tomography (CT) scan. The last patient to receive IV contrast with saline flush from a multi-dose vial at the clinic on the previous day was known to have chronic HCV genotype 1b (termed potential source, PS). Here we sought to confirm (via genetic analysis) the source of infection and to predict the minimal contaminating level of IV saline flush needed to transmit infectious virus to all patients. METHODS In order to confirm the source of infection, we sequenced the HCV E1E2 region in 7 CT patients, in PS, and in 2 control samples from unrelated patients also infected with HCV genotype 1b. A transmission probabilistic model was developed to predict the contamination volume of blood that would have been sufficient to transmit infectious virus to all patients. RESULTS Viral sequencing showed close clustering of the cases with the PS. The transmission probabilistic model predicted that contamination of the multi-dose saline vial with 0.6-8.7 microliters of blood would have been sufficient to transmit infectious virus to all patients. CONCLUSION Analysis of this unique cohort provides a new understanding of HCV transmission with respect to contaminating volumes and viral titers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |