245 Herbal Nettle and STAT6
| Autor: | Rutto L, Corley M, Davis K |
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| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Journal of Animal Science. 96:25-26 |
| ISSN: | 1525-3163 0021-8812 |
| DOI: | 10.1093/jas/sky404.058 |
| Popis: | The aim of this study was to evaluate the expression of the Signal Transducer and Activator of Transcription 6 (STAT6) gene in Haemonchus contortus(Hc) infected meat goats fed Herbal Nettle (HN; otherwise known as Stinging Nettle). Herbal Nettle was evaluated as a potential natural anthelmintic in meat goats exposed to Hc, a blood feeding, gastrointestinal nematode (GIN) that devastates the small ruminant industry worldwide. Herbal Nettle, has potential anti-inflammatory, anti-parasitic, and anti-hemorrhagic properties. In GIN infection, STAT6 initiates intestinal contractility which potentially contributes to GIN expulsion from the gut. In STAT6 negative mice, there is delayed GIN expulsion via reduced propulsive forces in the gut. Gene expression of STAT6 has not been evaluated in HN fed meat goats during Hc infection. Yearling Spanish, Myotonic and Kiko goats were fed HN supplemented corn soybean (CSB) diets (CSB only, CSB+25% HN =HN1, CSB+75% HN =HN2) for 52 days. Initial and bi-weekly weights, fecal egg counts (FEC) and packed cell volumes (PCV) were monitored. Intestinal tissues were collected from sacrificed animals, primers were designed to target the goat STAT6 gene and qReal Time PCR conducted to determine gene expression of STAT6. Data were analyzed using SAS. Means were considered significant at the 5% level of probability. Gene expression of STAT6 was reduced (P |
| Databáze: | OpenAIRE |
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