Exploiting the Reactivity of 1,2-Ketoamides: Enantioselective Synthesis of Functionalized Pyrrolidines and Pyrrolo-1,4-benzodiazepine-2,5-diones
| Autor: | Paola Acosta, Diana Becerra, Thierry Constantieux, Jairo Quiroga, Damien Bonne, Sébastien Goudedranche, Jean Rodriguez |
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| Přispěvatelé: | Facultad de Ciencias Exactas y Naturales, Institut des Sciences Moléculaires de Marseille (ISM2), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Institut de Chimie du CNRS (INC), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2015 |
| Předmět: |
Benzodiazepine
[CHIM.ORGA]Chemical Sciences/Organic chemistry Stereochemistry Chemistry medicine.drug_class Organic Chemistry Enantioselective synthesis Optically active 1 2-ketoamides enantioselective Michael addition Michael reaction medicine Reactivity (chemistry) benzodiazepine Sequence (medicine) |
| Zdroj: | SYNLETT SYNLETT, Georg Thieme Verlag, 2015, 26, pp.1591-1595. ⟨10.1055/s-0034-1378711⟩ SYNLETT, 2015, 26, pp.1591-1595. ⟨10.1055/s-0034-1378711⟩ |
| ISSN: | 1437-2096 0936-5214 |
| DOI: | 10.1055/s-0034-1378711 |
| Popis: | International audience; A new strategy for the synthesis of optically active pyrrolo[ 1,4]benzo- diazepine-2,5-diones has been developed. The approach is based on an initial Michael addition of functionalized 1,2-ketoamides on nitroalkenes, with a reduction–double cyclization sequence leading to the desired substituted benzodiazepine. |
| Databáze: | OpenAIRE |
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