Gadolinium-complexed Aβ-binding contrast agents for MRI diagnosis of Alzheimer's Disease
| Autor: | Nicholas G. Spencer, Balpreet Matharu, Franklyn A. Howe, Brian M. Austen |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Genetically modified mouse Pathology medicine.medical_specialty Transgene Gadolinium Contrast Media chemistry.chemical_element Mice Transgenic Plaque Amyloid Peptide Biosensing Techniques Mice Young Adult Cellular and Molecular Neuroscience chemistry.chemical_compound Endocrinology Alzheimer Disease medicine Animals Humans DOTA Tissue Distribution Mri scan Radioisotopes chemistry.chemical_classification Amyloid beta-Peptides Endocrine and Autonomic Systems Chemistry Brain General Medicine Magnetic Resonance Imaging Peptide Fragments Neurology Mri diagnosis Positron-Emission Tomography Cell penetration |
| Zdroj: | Neuropeptides. 53:63-70 |
| ISSN: | 0143-4179 |
| DOI: | 10.1016/j.npep.2015.07.001 |
| Popis: | MRI contrast agents, containing peptide sequences that bind β-amyloid and gadolinium ions ligated to DOTA have been synthesized for evaluation in early diagnosis of Alzheimer's Disease in transgenic mice models. A number of brain penetration modifications were incorporated and sufficient amounts of contrast agent in the brain were achieved only by addition of a cationic cell penetration sequence along with the use of microparticle assisted ultrasound activation. In the T1 mode of a MRI scan, the peptide (R2) illuminated areas of brain rich in amyloid plaques. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect