Preserved residual renal function is associated with lower oxidative stress in peritoneal dialysis patients
| Autor: | Denis Fouque, Fitsum Guebre-Egziabher, Sophie Ignace, Walid Arkouche, Jean-Paul Steghens |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Lipid Peroxides medicine.medical_specialty medicine.medical_treatment Renal function Kidney Peritoneal dialysis Lipid peroxidation chemistry.chemical_compound Malondialdehyde Internal medicine medicine Humans Dialysis Aged Transplantation Dialysis adequacy business.industry Middle Aged medicine.disease Oxidative Stress Cross-Sectional Studies Endocrinology chemistry Nephrology Multivariate Analysis Female Kidney Diseases Lipid Peroxidation Hemodialysis business Peritoneal Dialysis Kidney disease |
| Zdroj: | Nephrology Dialysis Transplantation. 24:1685-1689 |
| ISSN: | 1460-2385 0931-0509 |
| DOI: | 10.1093/ndt/gfp077 |
| Popis: | Background. Residual renal function (RRF) correlates with survival in peritoneal dialysis (PD). We investigated the association between oxidative stress and RRF in PD. Methods. Adequacy of dialysis, total and free malondialdehydes (MDA), and lipid hydroperoxides (LHP) were obtained from 23 stable PD patients. Results. Free MDA level decreased with total weekly Kt/ V urea (r = -0.51, P = 0.013) and urinary Kt/V (KRU) (r = -0.53, P = 0.009), but not with peritoneal Kt/V Similar results were found with LHP level. In multivariate analysis, total weekly Kt/V urea and KRU remained associated with free MDA and LHP, independently of gender, nutritional or inflammatory status, and peritoneal permeability. Conclusion. A preserved RRF is associated with lower serum levels of lipid peroxidation products among PD patients. |
| Databáze: | OpenAIRE |
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