The role of angiotensin(1-7) in renal vasculature of the rat
| Autor: | Richard P. E. van Dokkum, Leo E. Deelman, Robert H. Henning, Anton J.M. Roks, Dick de Zeeuw, Peter Ochodnický, Els A van der Wouden |
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| Přispěvatelé: | Groningen University Institute for Drug Exploration (GUIDE), Groningen Kidney Center (GKC), Vascular Ageing Programme (VAP), Groningen Institute for Organ Transplantation (GIOT), Other departments |
| Rok vydání: | 2006 |
| Předmět: |
STIMULATION
Male medicine.medical_specialty Angiotensin receptor kidney vasculature Physiology Kidney Glomerulus In Vitro Techniques Renal Circulation Renal Artery BRADYKININ Internal medicine NATRIURETIC ACTION Renin–angiotensin system Internal Medicine medicine Animals Vasoconstrictor Agents Anesthesia Rats Wistar SPONTANEOUSLY HYPERTENSIVE-RATS angiotensin(1-7) Antihypertensive Agents Kidney AFFERENT ARTERIOLES Angiotensin II receptor type 1 Renal circulation NITRIC-OXIDE biology business.industry Angiotensin II CONSCIOUS RATS Angiotensin-converting enzyme RECEPTOR SUBTYPES Peptide Fragments Rats Arterioles Endocrinology medicine.anatomical_structure Renal blood flow biology.protein Angiotensin I Cardiology and Cardiovascular Medicine business INHIBITORS |
| Zdroj: | Journal of Hypertension, 24(10), 1971-1978. LIPPINCOTT WILLIAMS & WILKINS Journal of hypertension, 24(10), 1971-1978. Lippincott Williams and Wilkins |
| ISSN: | 0263-6352 |
| Popis: | Objective Angiotensin(1-7) is an active component of the renin-angiotensin-aldosterone system. Its exact role in renal vascular function is unclear. We therefore studied the effects of angiotensin(1-7) on the renal vasculature in vitro and in vivo.Methods Isolated small renal arteries were studied in an arteriograph system by constructing concentration response curves to angiotensin II, without and with angiotensin(1-7). In isolated perfused kidneys, the response of angiotensin II on renal vascular resistance was measured without and with angiotensin(1-7). The influence of angiotensin(1-7) on angiotensin II-induced glomerular afferent and efferent constriction was assessed with intravital microscopy in vivo under anaesthesia. In freely moving rats, we studied the effect of angiotensin(1-7) on angiotensin II-induced reduction of renal blood flow with an electromagnetic flow probe.Results Angiotensin(1-7) alone had no effect on the renal vasculature in any of the experiments. In vitro, angiotensin(1-7) antagonized angiotensin-II-induced constriction of isolated renal arteries (9.71 +/- 1.21 and 3.20 +/- 0.57%, for control and angiotensin(1-7) pre-treated arteries, respectively; P Conclusion Angiotensin(1-7) antagonizes angiotensin II in renal vessels in vitro, but does not appear to have a major function in normal physiological regulation of renal vascular function in vivo. |
| Databáze: | OpenAIRE |
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