Pituitary-Thyroid Function in Trophoblastic Disease
| Autor: | Yoshiaki Kawai, Kaichiro Ishibashi, Michishige Noguchi, Kiyoshi Miyai, Osamu Tanizawa, Yuichi Kumahara, Toshihide Yamamoto, Mizuo Azukizawa |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Adult
Thyroid Hormones endocrine system medicine.medical_specialty Pituitary gland Endocrinology Diabetes and Metabolism Clinical Biochemistry Thyroid Gland Thyrotropin Thyrotropin-releasing hormone Trophoblastic Neoplasms Chorionic Gonadotropin Biochemistry Thyroxine-Binding Proteins Endocrinology Pregnancy Internal medicine medicine Humans Thyrotropin-Releasing Hormone Triiodothyronine business.industry Biochemistry (medical) Thyroid Choriocarcinoma Radioimmunoassay medicine.disease Thyroxine medicine.anatomical_structure Pituitary Gland Uterine Neoplasms Female Thyroid function business Hormone |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 42:254-259 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-42-2-254 |
| Popis: | Pituitary-thyroid function was assessed in 12 patients with trophoblastic disease (4 hydatidiform mole, 3 invasive mole, and 5 choriocarcinoma). Thyroid-stimulating activity was detectable, by means of the McKenzie bioassay, in 6 patients (Group 1) but not in the other 6 patients (Group 2). In Group 1 serum thyrotropin (TSH) determined by radioimmunoassay was mostly undetectable and did not respond to the administration of thyrotropin-releasing hormone (TRH) determined by radioimmunoassay was mostly undetectable and did not respond to the administration of thyrotropin-releasing hormone (TRH), while in Group 2 basal TSH was detectable in half of the patients and responded to TRH in all cases. Serum concentrations of total thyroxine (T4) (18.7 +/- 2.0 mug/100 ml, mean +/- SE), free T4 (4.9 +/- 0.04 ng/100 ml), total triiodothyronine (T3) (352 +/- 72 ng/100 ml), and free T3 (0.57 +/- 0.11 ng/100 ml) in Group 1 were statistically greater than those in Group 2 (total T4, 9.2 +/- 1.0 mug/100 ml, free T4, 2.0 +/- 0.2 ng/100 ml; total T3 156 +/- 20 ng/100 ml, and free T3 0.23 +/- 0.03 ng/100 ml). Free T4 and T3 fractions were within normal limits in both groups. After treatment of 5 patients in Group 1, the thyroid stimulating activity determined by bioassay dropped to undetectable levels, the serum concentrations of thyroid hormones decreased to normal limits, and TSH response to TRH became positive. These findings indicate that an abnormal thyroid stimulator, derived from the trophoblastic tissue, stimulated the thyroid hormone secretion from the thyroid gland and in turn suppressed TSH response to TRH in some patients with trophoblastic disease. |
| Databáze: | OpenAIRE |
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