Moderate alcohol consumption is associated with improved insulin sensitivity, reduced basal insulin secretion rate and lower fasting glucagon concentration in healthy women

Autor: Emmanuel Disse, Andrea Mari, Fabrice Bonnet, Maurice Laville, Kurt Højlund, Christian Anderwald, Pier Marco Piatti, B. Balkau
Přispěvatelé: Foie, métabolismes et cancer, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), EU [QLG1-CT-2001-01252], AstraZeneca (Sweden), Merck Serono, France, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)
Rok vydání: 2012
Předmět:
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
Alcohol
Blood Pressure
Type 2 diabetes
Insulin clearance
MESH: Glucose Clamp Technique
chemistry.chemical_compound
0302 clinical medicine
Surveys and Questionnaires
Insulin
030212 general & internal medicine
Glucose tolerance test
MESH: Middle Aged
medicine.diagnostic_test
Insulin secretion
MESH: Glucagon
MESH: Blood Pressure
Fasting
Glucose clamp technique
Middle Aged
3. Good health
MESH: Insulin Resistance
Female
Alcohol consumption
Adult
medicine.medical_specialty
Alcohol Drinking
MESH: Glucose Tolerance Test
MESH: Fasting
030209 endocrinology & metabolism
MESH: Insulin
Glucagon
03 medical and health sciences
Insulin resistance
Internal medicine
Internal Medicine
medicine
Humans
MESH: Humans
business.industry
MESH: Questionnaires
MESH: Adult
[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
Glucose Tolerance Test
medicine.disease
Endocrinology
chemistry
Glucose Clamp Technique
Women's Health
Insulin Resistance
business
MESH: Women's Health
MESH: Female
MESH: Alcohol Drinking
Zdroj: Diabetologia (Berl.) 55 (2012): 3228–3237. doi:10.1007/s00125-012-2701-3
info:cnr-pdr/source/autori:Bonnet, F.;Disse, E.;Laville, M.;Mari, A.;Hojlund, K.;Anderwald, C.H.;Piatti, P.;Balkau, B./titolo:Moderate alcohol consumption is associated with improved insulin sensitivity, reduced basal insulin secretion rate and lower fasting glucagon concentration in healthy women/doi:10.1007%2Fs00125-012-2701-3/rivista:Diabetologia (Berl.)/anno:2012/pagina_da:3228/pagina_a:3237/intervallo_pagine:3228–3237/volume:55
Diabetologia
Diabetologia, Springer Verlag, 2012, 55 (12), pp.3228-37. ⟨10.1007/s00125-012-2701-3⟩
Bonnet, F, Disse, E, Laville, M, Mari, A, Hojlund, K, Anderwald, C H, Piatti, P, Balkau, B & RISC Study Group 2012, ' Moderate alcohol consumption is associated with improved insulin sensitivity, reduced basal insulin secretion rate and lower fasting glucagon concentration in healthy women ', Diabetologia, vol. 55, no. 12, pp. 3228-37 . https://doi.org/10.1007/s00125-012-2701-3
Diabetologia, 2012, 55 (12), pp.3228-37. ⟨10.1007/s00125-012-2701-3⟩
ISSN: 1432-0428
0012-186X
DOI: 10.1007/s00125-012-2701-3
Popis: Moderate alcohol consumption is associated with a reduced risk of type 2 diabetes with a stronger effect in women. As the underlying mechanisms remain poorly characterised, we investigated its relationship with insulin resistance, insulin secretion, clearance of insulin and glucagon concentration.One-thousand two-hundred and seventy-six non-diabetic individuals from the RISC (relationship between insulin sensitivity and cardiovascular disease) study without high alcohol consumption were studied; all had a euglycaemic-hyperinsulinaemic clamp and an OGTT with assessment of insulin sensitivity, secretion and clearance.Alcohol consumption was positively associated with insulin sensitivity in women (β = 0.15, p ( trend ) = 0.005) and in men (β = 0.07, p ( trend ) = 0.07) after controlling for age, centre, waist, smoking and physical activity. In women, this association persisted after adjustment for adiponectin but was attenuated after controlling for HDL-cholesterol, suggesting that part of the protection is related to a higher HDL-cholesterol concentration. Higher alcohol consumption was associated with lower basal insulin secretion in women only (β = -0.10, p ( trend ) = 0.004) and this association persisted after adjustment for insulin sensitivity. In men, increasing alcohol consumption was associated with enhanced insulin clearance and increased fasting NEFA concentrations, independently of insulin sensitivity. Fasting glucagon decreased with increasing alcohol in women only (abstainers 9.2 ± 4.4;28 g/week 8.6 ± 4.0; 28-64 g/week 8.1 ± 3.7;64 g/week 7.5 ± 3.1 pmol/l; p ( trend ) = 0.01).Light-to-moderate alcohol consumption was associated in healthy women with enhanced insulin sensitivity, reduced basal insulin secretion rate and lower fasting plasma glucagon concentration, providing consistent mechanisms for the reduced risk of diabetes.
Databáze: OpenAIRE
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