A novel nomogram to predict the reliability of estimated glomerular filtration rate formulae in oncology patients

Autor: Liu Huang, Gang Xu, Chummun Vanisha, Yunfeng Han, Shuwang Ge, Yichun Cheng
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Cancer Research
030232 urology & nephrology
Logistic regression
Kidney Function Tests
urologic and male genital diseases
Nomogram
chemistry.chemical_compound
0302 clinical medicine
Neoplasms
Renal Insufficiency
Estimated glomerular filtration rate
Reliability (statistics)
reproductive and urinary physiology
Aged
80 and over
MDRD formula
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
female genital diseases and pregnancy complications
Concordance correlation coefficient
Oncology
030220 oncology & carcinogenesis
Creatinine
Female
Measured glomerular filtration rate
Research Article
Glomerular Filtration Rate
Adult
medicine.medical_specialty
China
Urology
Coverage probability
Renal function
lcsh:RC254-282
03 medical and health sciences
Young Adult
Predictive Value of Tests
Genetics
medicine
Humans
Aged
Retrospective Studies
business.industry
Reproducibility of Results
medicine.disease
Nomograms
chemistry
business
Kidney disease
Zdroj: BMC Cancer, Vol 20, Iss 1, Pp 1-9 (2020)
BMC Cancer
ISSN: 1471-2407
Popis: Background Formulae of estimated glomerular filtration rate (eGFR) based on serum creatinine (Scr) are routinely used in oncology patients, however, they are inaccurate in some populations. Our aim was to assess the agreement of eGFR formulae and thereby build a nomogram to predict the reliability of estimates. Methods Measured GFR (mGFR) using isotope from 445 oncology patients were compared with eGFR from six formulae (Cockcroft-Gault, Modification of Diet in Renal Disease (MDRD), modified MDRD formulae for Chinese (C-MDRD), Chronic Kidney Disease Epidemiology (CKD-EPI) Collaboration, Wright and full age spectrum (FAS)). Bias, precision and accuracy of eGFR formulae were examined. We also evaluated statistics of agreement: the total deviation index (TDI), the concordance correlation coefficient (CCC) and the coverage probability (CP). Multivariate logistic regression was applied to identify characteristics associated with inaccurate eGFR and construct a predictive nomogram. Results All eGFR formulae tended to overestimate the eGFR. The percentage of patients with eGFR within 30% the mGFR ranged from 38.0 to 62.8%. Cockcroft-Gault and MDRD showed low bias and high precision. The MDRD formula exhibited lowest TDI, meaning that 90% of estimations ranged from − 36 to 36% of mGFR. Multivariate logistic regression showed that inaccuracy of MDRD was found in elderly patients or in patients with eGFR greater than 120 ml/min. A nomogram was constructed to help oncologists to predict the risk of inaccuracy of eGFR. The calibration curve showed good agreement. Conclusions Our results suggest that the error of eGFR by any formulae was common and wide in Chinese oncology patients. Our nomogram may assist oncologists in decision-making when mGFR is needed.
Databáze: OpenAIRE
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