A novel nomogram to predict the reliability of estimated glomerular filtration rate formulae in oncology patients
Autor: | Liu Huang, Gang Xu, Chummun Vanisha, Yunfeng Han, Shuwang Ge, Yichun Cheng |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Male
Cancer Research 030232 urology & nephrology Logistic regression Kidney Function Tests urologic and male genital diseases Nomogram chemistry.chemical_compound 0302 clinical medicine Neoplasms Renal Insufficiency Estimated glomerular filtration rate Reliability (statistics) reproductive and urinary physiology Aged 80 and over MDRD formula Middle Aged lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens female genital diseases and pregnancy complications Concordance correlation coefficient Oncology 030220 oncology & carcinogenesis Creatinine Female Measured glomerular filtration rate Research Article Glomerular Filtration Rate Adult medicine.medical_specialty China Urology Coverage probability Renal function lcsh:RC254-282 03 medical and health sciences Young Adult Predictive Value of Tests Genetics medicine Humans Aged Retrospective Studies business.industry Reproducibility of Results medicine.disease Nomograms chemistry business Kidney disease |
Zdroj: | BMC Cancer, Vol 20, Iss 1, Pp 1-9 (2020) BMC Cancer |
ISSN: | 1471-2407 |
Popis: | Background Formulae of estimated glomerular filtration rate (eGFR) based on serum creatinine (Scr) are routinely used in oncology patients, however, they are inaccurate in some populations. Our aim was to assess the agreement of eGFR formulae and thereby build a nomogram to predict the reliability of estimates. Methods Measured GFR (mGFR) using isotope from 445 oncology patients were compared with eGFR from six formulae (Cockcroft-Gault, Modification of Diet in Renal Disease (MDRD), modified MDRD formulae for Chinese (C-MDRD), Chronic Kidney Disease Epidemiology (CKD-EPI) Collaboration, Wright and full age spectrum (FAS)). Bias, precision and accuracy of eGFR formulae were examined. We also evaluated statistics of agreement: the total deviation index (TDI), the concordance correlation coefficient (CCC) and the coverage probability (CP). Multivariate logistic regression was applied to identify characteristics associated with inaccurate eGFR and construct a predictive nomogram. Results All eGFR formulae tended to overestimate the eGFR. The percentage of patients with eGFR within 30% the mGFR ranged from 38.0 to 62.8%. Cockcroft-Gault and MDRD showed low bias and high precision. The MDRD formula exhibited lowest TDI, meaning that 90% of estimations ranged from − 36 to 36% of mGFR. Multivariate logistic regression showed that inaccuracy of MDRD was found in elderly patients or in patients with eGFR greater than 120 ml/min. A nomogram was constructed to help oncologists to predict the risk of inaccuracy of eGFR. The calibration curve showed good agreement. Conclusions Our results suggest that the error of eGFR by any formulae was common and wide in Chinese oncology patients. Our nomogram may assist oncologists in decision-making when mGFR is needed. |
Databáze: | OpenAIRE |
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