Deep brain stimulation in Lesch-Nyhan disease: outcomes from the patient's perspective
Autor: | Gastón Schechtmann, Kristina Tedroff, David J. Schretlen, Hyder A. Jinnah, Jocelyne Bloch, Adam C. Cotton, Diana Djurfeldt, Jasper E. Visser, Laura Cif, Victoria Gonzalez |
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Rok vydání: | 2021 |
Předmět: |
Male
030506 rehabilitation Pediatrics medicine.medical_specialty Deep brain stimulation Adolescent Lesch-Nyhan Syndrome Deep Brain Stimulation medicine.medical_treatment Disease Globus Pallidus Article Young Adult 03 medical and health sciences 0302 clinical medicine Developmental Neuroscience medicine Humans Effective treatment Child Adverse effect High rate business.industry Perspective (graphical) Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] Response Variability Patient Outcome Assessment Treatment Outcome Lesch-Nyhan Disease Child Preschool Pediatrics Perinatology and Child Health Female Neurology (clinical) 0305 other medical science business 030217 neurology & neurosurgery |
Zdroj: | Developmental Medicine & Child Neurology, 63, 963-968 Developmental medicine and child neurology, vol. 63, no. 8, pp. 963-968 Developmental medicine and child neurology Developmental Medicine & Child Neurology, 63, 8, pp. 963-968 |
ISSN: | 0012-1622 |
Popis: | Contains fulltext : 238526.pdf (Publisher’s version ) (Open Access) AIM: To provide insight into outcome and long-term safety and efficacy of deep brain stimulation (DBS), from the perspective of individuals with Lesch-Nyhan disease (LND) and their families. METHOD: We used patient-centered outcome measures to assess long-term outcomes of DBS for 14 individuals (mean [SD] age 10y 10mo [5y 6mo], range 5-23y, all males) with LND, after an average duration of 5y 6mo (range 11mo-10y 5mo) after surgery. We compared these results with a comprehensive review of previously published cases. RESULTS: Patients and their families reported that DBS of the globus pallidus can be effective both for motor and behavioral disturbances in LND. However, outcome measures were often not significantly changed owing to substantial variability among individuals, and were overall less positive than in previous reports based on clinician assessments. In addition, there was an unexpectedly high rate of adverse events, tempering overall enthusiasm for the procedure. INTERPRETATION: Although DBS might be an effective treatment for LND, more research is needed to understand the reasons for response variability and the unusually high rates of adverse events before DBS can be recommended for these patients. What this paper adds Individuals with Lesch-Nyhan disease and their families report variable efficacy of deep brain stimulation. Long-term outcomes are associated with a high adverse event rate. |
Databáze: | OpenAIRE |
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