Prognostic value of hematological parameters in patients with paraquat poisoning
| Autor: | Cheng-Fan Zhou, Hong Zhang, Qi-Xing Zhu, Zhi-Ming Luo, Deng-Chuan Zhou |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Paraquat medicine.medical_specialty Adolescent Neutrophils Leukocyte Counts Gastroenterology Article Leukocyte Count Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine Humans Medicine In patient Aged Retrospective Studies Aged 80 and over Blood Chemical Analysis Blood Cells Multidisciplinary Receiver operating characteristic Herbicides business.industry Curve analysis Retrospective cohort study Middle Aged Prognosis PARAQUAT POISONING ROC Curve 030220 oncology & carcinogenesis Female business 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep36235 |
| Popis: | Paraquat (PQ) is a non-selective contact herbicide, and acute PQ poisoning has a high mortality. The aim of the present study is to evaluate the prognostic value of hematological parameters in patients with acute PQ poisoning. We retrospectively reviewed the records of patients with acute PQ poisoning from January 2010 to December 2015 at the First Affiliated Hospital, Anhui Medical University (Hefei, China). A total of 202 patients were included in the study, and the 30-day mortality was 51.98%. Leukocyte, neutrophil counts and neutrophil-lymphocyte ratio (NLR) were significantly higher in non-survivors than in survivors. In the receiver operating characteristic (ROC) curve analysis, the NLR had an area of 0.916(95%CI, 0.877–0.954) and the optimal cut-off value was 10.57 (sensitivity, 86.70%; specificity, 83.51%; Youden’s index, 0.702). The leukocyte counts had an area of 0.849(95%CI, 0.796–0.902) and the optimal cut-off value was 13.15 × 103/mm3 (sensitivity, 77.10%; specificity, 83.50%; Youden’s index, 0.606). The neutrophil counts had an area of 0.878(95%CI, 0.830–0.925) and the optimal cut-off value was 10.10 × 103/mm3 (sensitivity, 83.80%; specificity, 79.38%; Youden’s index, 0.632). NLR, leukocyte and neutrophil counts are associated with the 30-day mortality, which may be useful and simple parameters in predicting the prognosis of PQ poisoning. |
| Databáze: | OpenAIRE |
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