Surface-modified nanoparticles as anti-biofilm filler for dental polymers
| Autor: | Ervin I. Weiss, Nathan Zaltsman, Nurit Beyth, Shaul Beyth, Andrei C. Ionescu, Eugenio Brambilla |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Tertiary amine
Compressive Strength Polymers Physiology Nanoparticle lcsh:Medicine 02 engineering and technology Pathology and Laboratory Medicine Contact angle Streptococcus mutans chemistry.chemical_compound 0302 clinical medicine Medicine and Health Sciences Nanotechnology Amines lcsh:Science chemistry.chemical_classification Multidisciplinary Chemistry Antimicrobials Organic Compounds Drugs Polymer 021001 nanoscience & nanotechnology Silicon Dioxide Anti-Bacterial Agents Bacterial Pathogens Body Fluids Monomer Compressive strength Macromolecules Medical Microbiology Physical Sciences Engineering and Technology Pathogens Anatomy 0210 nano-technology Antibacterial activity Hydrophobic and Hydrophilic Interactions Research Article Surface Properties Materials by Structure Materials Science Microbial Sensitivity Tests Composite Resins Microbiology 03 medical and health sciences Microbial Control Ammonium Saliva Microbial Pathogens Pharmacology Microbial Viability Bacteria lcsh:R Organic Chemistry Chemical Compounds Organisms Biology and Life Sciences Streptococcus Bacteriology 030206 dentistry Polymer Chemistry Quaternary Ammonium Compounds Chemical engineering Biofilms Acrylics Nanoparticles Antibacterials lcsh:Q Bacterial Biofilms |
| Zdroj: | PLoS ONE PLoS ONE, Vol 12, Iss 12, p e0189397 (2017) |
| ISSN: | 1932-6203 |
| Popis: | The objective of the study was to synthesis silica nanoparticles modified with (i) a tertiary amine bearing two t-cinnamaldehyde substituents or (ii) dimethyl-octyl ammonium, alongside the well-studied quaternary ammonium polyethyleneimine nanoparticles. These were to be evaluated for their chemical and mechanical properties, as well for antibacterial and antibiofilm activity. Samples were incorporated in commercial dental resin material and the degree of monomer conversion, mechanical strength, and water contact angle were tested to characterize the effect of the nanoparticles on resin material. Antibacterial activity was evaluated with the direct contact test and the biofilm inhibition test against Streptococcus mutans. Addition of cinnamaldehyde-modified particles preserved the degree of conversion and compressive strength of the base material and increased surface hydrophobicity. Quaternary ammonium functional groups led to a decrease in the degree of conversion and to low compressive strength, without altering the hydrophilic nature of the base material. In the direct contact test and the anti-biofilm test, the polyethyleneimine particles exhibited the strongest antibacterial effect. The cinnamaldehyde-modified particles displayed antibiofilm activity, silica particles with quaternary ammonium were ineffective. Immobilization of t-cinnamaldehyde onto a solid surface via amine linkers provided a better alternative to the well-known quaternary ammonium bactericides. |
| Databáze: | OpenAIRE |
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