Efficient Synthesis of Highly Functionalized Cyclic Aminimides

Autor:	Bongjin Moon, Sangbae Han, Do-hyung Kim
Rok vydání:	2005
Předmět:	chemistry.chemical_compound chemistry Organic Chemistry Heteroatom Substituent Organic chemistry General Medicine Physical and Theoretical Chemistry Condensation reaction Ring (chemistry) Combinatorial synthesis Combinatorial chemistry Biochemistry
Zdroj:	Organic Letters. 7:3359-3361
ISSN:	1523-7052 1523-7060
DOI:	10.1021/ol051270v
Popis:	[reaction: see text]. Simple condensation reactions of various alpha,beta-epoxy or alpha,beta-aziridinyl methyl esters with 1,1-dialkyl hydrazines provided cyclic aminimides (1,1-dialkyl-3-oxopyrazolidines) with a heteroatom substituent at the 4-position in good yields. The reaction proceeds smoothly, without any coreagent, providing the product as an easily isolable precipitate. The reaction is expected to be a good candidate for combinatorial synthesis of a highly functionalized five-membered ring scaffold. The scope and limitations of this reaction were investigated by varying the substituents R(1)-R(5).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e913db2d6198b20da8aec36766a1344 https://doi.org/10.1021/ol051270v Zobrazit plný text záznamu